摘要
血清HBsAg阴性者肝组织或血清中仍可检出HBV DNA,此现象称为隐匿性HBV感染(occult hepatitis B virus infection,OBI)。OBI对保障输血安全、临床诊断和HBV流行病学监控带来很大困难,进一步阐明其机制有利于OBI的预防和治疗。本文综述了近年来对OBI发生机制的研究进展、OBI对血液安全的影响以及核酸检测工作对血液安全的促进作用。
HBV DNA can be detected in one＇s serum or liver who is HBsAg negative in serum, and this phenomenon is called occult hepatitis B virus infection（OBI）. OBI makes it particularly difficult to ensure blood transfusion safety, make clinical diagnosis and implement epidemiological monitoring of HBV. Further study for the mechanism is beneficial for its prevention and treatment. This paper reviewed the research progress of the mechanism of OBI in recent years, the impact on blood safety, and the promoting effect on blood safety of nucleic acid test.
出处
《临床医学工程》
2014年第5期670-672,共3页
Clinical Medicine & Engineering
关键词
隐匿性乙肝病毒感染
基因突变
核酸检测
血液安全
Occult hepatitis B virus infection
Gene mutation
Nucleic acid detection
Blood safety
