摘要
目的探讨血清胃蛋白酶原(PG)与抗Hp IgG抗体联合检测对胃溃疡早期筛查的临床意义。方法选择首次确诊胃溃疡的65例患者作为溃疡组,将同期65例健康体检者作为对照组。采用胶乳增强免疫透射比浊法检测其血清PGⅠ、PGⅡ,并计算PGⅠ/Ⅱ比值(PGR)。采用酶联免疫吸附测定(ELISA)检测受检者血清抗Hp IgG抗体。结果胃溃疡组患者血清PGⅠ、PGⅡ的平均值分别为(167.14±22.43)、(26.68±11.24)ng/mL,PGR为8.07±1.19;对照组受检者血清PGⅠ、PGⅡ的平均值分别为(52.15±20.17)、(11.26±7.68)ng/mL,PGR为3.48±1.92。两组PGⅠ、PGⅡ及PGR的差异具有统计学意义(P<0.05)。溃疡组患者血清抗Hp IgG抗阳性率为80.5%,显著高于对照组(26.3%)(P<0.05)。Hp感染阳性组受检者血清PGⅠ、PGⅡ及PGR显著高于阴性组(P<0.05)。结论血清PG与抗Hp IgG抗体联合检测可作为胃溃疡早期的筛查指标。
Objective To investigate the clinical significance of combined detection of serum pepsinogen （PG） and anti-Hp IgG antibody in early screening for gastric ulcer .Methods 65 patients confirmed as gastric ulcer for the first time were selected as ulcer group ,while 65 healthy people in the same period as the control group .Transmission detection using latex enhanced immune nephe-lometry was adopted to detect their serum PG Ⅰ ,PG Ⅱ and the PG Ⅰ /PG Ⅱ ratio （PGR） was calculated .Enzyme-linked immu-nosorbent assay（ELISA） was used to detect serum anti-Hp IgG antibody .Results The average concentration of serum PG Ⅰand PG Ⅱof patients in the ulcer group were （167 .14 ± 22 .43） ,（26 .68 ± 11 .24） ng/mL ,respectively ,and PGR was 8 .07 ± 1 .19 .The average concentration of serum PG Ⅰand PG Ⅱof subjects in the control group were （52 .15 ± 20 .17） ,（11 .26 ± 7 .68） ng/mL ,re-spectively ,and PGR was 3 .48 ± 1 .92 .The differences of PGⅠ ,PGⅡand PGR between the two group showed statistical significance （P〈0 .05） .The positive rate of serum anti-Hp IgG antibody of patients in the ulcer group was 80 .5% ,which was obviously higher than that in the control group（26 .3% ）（P〈0 .05） .The serum PGⅠ ,PGⅡand PGR of subjects in Hp infection positive group were markedly higher than those in the negative group（P〈0 .05） .Conclusion Combined detection of serum PG and anti-Hp IgG anti-body may be used as an screening indicators for early gastric ulcer .
出处
《国际检验医学杂志》
CAS
2014年第9期1122-1123,共2页
International Journal of Laboratory Medicine
