摘要
目的探讨慢性萎缩性胃炎(CAG)合并幽门螺杆菌(Hp)感染患者胃蛋白酶原(PG)及胃泌素水平的变化及其临床意义。方法将60例CAG患者,根据有无Hp感染分为Hp阳性组和Hp阴性组,每组30例。检测并对比两组患者血清PG及胃泌素水平。结果 Hp阳性组患者PGⅠ水平、PGⅠ/PGⅡ比值均低于Hp阴性组患者,血清胃泌素高于Hp阴性组(均P<0.05)。结论与未感染Hp的CAG患者比较,CAG合并Hp感染患者PGⅠ和PGⅠ/PGⅡ比值降低,血清胃泌素水平升高。检测CAG伴Hp感染者PG及血清胃泌素水平,对评估病情及疗效有重要的临床意义。
Objective To explore the changes of pepsinogen and gastrin levels in patients with chronic atrophic gastritis(CAG) complicated with Helicobacter pylori(Hp) infection and its clinical significance.Methods Sixty patients with CAG complicated with Hp infection were divided into Hp positive group and Hp negative group according to the presence or absence of Hp infection,with 30 cases in each group.The levels of serum PG and gastrin were detected and compared between the two groups.Results The level of PG Ⅰ and ratio of PG Ⅰ to PG Ⅱ in the Hp positive group were lower than those in the Hp negative group,whereas the level of serum gastrin was higher than that in the Hp negative group(all P<0.05).Conclusion Compared to CAG patients without Hp infection,the level of PG Ⅰ and ratio of PG Ⅰ to PG Ⅱ decrease in patients with CAG complicated with Hp infection,and the level of serum gastrin increases.Detecting the levels of PG and serum gastrin in CAG patients with Hp infection,is of great clinical significance in disease and efficacy evaluation.
作者
邵艾伦
董筠
SHAO Ai-lun;DONG Jun(Graduate School,Nanjing University of Chinese Medicine,Jiangsu 210000,China;Department of Gastroenterology,Affiliated Hospital of Nanjing University of Chinese Medicine,Jiangsu 210000,China)
出处
《广西医学》
CAS
2019年第20期2564-2566,共3页
Guangxi Medical Journal
基金
江苏省中医药局科技项目(YB2017011)
