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1-脱氧-D-木酮糖醇-5-磷酸还原异构酶(DXR)作为新的药物靶点的研究进展 被引量：1

Research progress of 1-deoxy-d-xylulose-5-phosphate reductoisomerase(DXR) as new drug target
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摘要 植物、藻类和细菌等可利用2C-甲基-D-赤藓糖醇-4-磷酸(MEP)途径生物合成类异戊二烯前体异戊酰焦磷酸(IPP)及其异构体二甲烯丙基焦磷酸(DMAPP)等生长所必须的前体,因此MEP途径作为除草剂、抗菌药物和抗疟疾药物的药物靶点可用于新药开发。其中MEP途径中的第二个酶1-脱氧-D-木酮糖醇-5-磷酸还原异构酶(DXR)是研究最为广泛的靶点,膦胺霉素即为该酶的抑制剂。本综述主要介绍MEP途径、DXR及其抑制剂的研究进展。 Isopentenyl diophospaste （IPP） and its isomer dimethylallyl diophospaste （DMAPP） can be synthesized through 2C-methylerythritol-4-phosphate （MEP） pathway in plants, algae and eubacteria, which are common precursors of isoprenoids. Therefore, MEP pathway can be used as a new drug target for development of herbicides, antibiotics and anti- malarial drugs. 1-deoxy-d-xylulose-5-phosphate reductoisomerase （DXR） is currently the most widely investigated drug target. Fosmidomycin is one of its inhibitors. This review briefly describes the reseach progress on MEP pathway, DXR and its inhibitors.
作者 陈习平 谢丽萍 胡又佳
机构地区 中国医药工业研究院总院上海医药工业研究院创新药物与制药工艺国家重点实验室
出处 《世界临床药物》 CAS 2014年第5期319-320,I0001,I0002,I0003,共5页 World Clinical Drug
基金 国家"重大新药创制"科技重大专项(2011ZX09203-001-06) 上海自然科学基金项目"上海市自然科学基金(11ZR1435200)" 中国医药集团新产品开发基金2011HY03-1和2011HY19 上海市科委科技支撑项目13431900204
关键词 MEP途径 1-脱氧-D-木酮糖醇-5-磷酸还原异构(DXR) 抑制剂 膦胺霉素 药物靶点 MEP pathway 1-deoxy-d-xylulose-5-phosphate reductoisomerase （DXR） inhibitors fosmidomycin drug target
分类号 R971 [医药卫生—药品]
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世界临床药物
2014年 第5期

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