摘要
目的探讨乳腺癌免疫组化亚型的超声特征。方法将157例经病理证实为乳腺癌的患者根据免疫组化结果分为三阴组（29例）、激素受体阳性组（95例）及人表皮生长因子受体2（HER2）阳性组（33例）。对比分析各组患者的临床、病理及超声相关资料。结果①三阴组腋窝淋巴结转移率为55．2％，高于激素受体阳性组（31．6％）和HER2阳性组（51．5％），差异有统计学意义（P〈0．05）；三阴组、HER2阳性组及激素受体阳性组的发病年龄分别为（46．28±13．64）岁、（52．78±10．29）岁及（54．24±10．20）岁，差异有统计学意义（P〈0．05）。②三阴组、HER2阳性组及激素受体阳性组肿块边缘呈毛刺征和内部有微钙化者分别占31．0％、36．4％、66．3％和55．2％、72．7％、45．3％，超声弹性成像评分为4。5分者分别占89．7％、90．9％、92．6％，应变率分别为（3．06±0．33）s^-1、（2．90±0．38）s^-1、（2．84±0．36）s^-1，差异均有统计学意义（P〈0．05）。结论乳腺癌超声图像表现与其免疫组化亚型之间具有较好的相关关系，超声检查可为其治疗及预后评估提供重要信息。
Objective To investigate the ultrasonographic features of immunohistochemical subtypes in patients with breast cancer.Methods One hundred and fifty-seven patients with breast cancer confirmed by pathology were divided into triple-negative breast cancer（TNBC） group （n=29）, hormone receptor positive group （n=95） and HER2 positive group （n=33）. The clinical, histopathological, ultrasonographic characteristics of the patients in the three groups were comparatively analyzed. Results ①The percentage of axillary lymph node metastasis in TNBC group （55.2 %） was higer compared with that in hormone receptor positive group（31.6%） and HER2 positive group （51.5 %）,the differences were significant（P 〈 0.05）. The ages of onset in the three groups were （46.28±13.64）, （52.78±10.29） and（54.24±10.20）,respectivley （P 〈 0.05）. ②The percentage of spiculation and microcalcification in ultrasonographic characteristics in the three groups were 31.0%, 36.4%, 66.3% and 55.2%, 72.7% ,45.3% ,respectively,which were significantly differences （P 〈 0.05）.The elastographic scores from 4 to 5 accounted for 89.7%, 90.9%, 92.6%, and the strain rates were （3.06 ±0.33）s-1, （2.90 ±0.38）s-1, （2.84 ±0.36）s-1, respectively （P 〈 0.05）. Conclusion The uhrasonographic characteristics of breast cancer have good correlation with its immunohistochemical subtypes and can provide important information for the treatment and prognostic evaluation.
出处
《临床超声医学杂志》
2014年第4期249-252,共4页
Journal of Clinical Ultrasound in Medicine
关键词
超声检查
弹性成像
乳腺癌
三阴性
Ultrasonography
Elastography
Breast cancer, triple-negative
