摘要
背景 Kappa角是指人眼视轴与瞳孔轴相交所成的角度,是调整角膜屈光手术的切削中心和设计斜视手术矫正量的重要参数.以往的研究表明Kappa角的大小和变化受年龄和屈光状态的影响,其检测结果也受检测仪器精度的影响. 目的 采用温州医科大学眼视光学院实验室设计的Kappa角测量仪评价正常人眼轴长度、角膜曲率、前房深度对Kappa角变化的影响,并进行权重分析.方法 采用横断面研究方法,于2009年12月至2010年8月纳入年龄18 ～38岁、平均屈光度为-1.0D的健康志愿者50人,采用温州医科大学眼视光学院实验室设计的Kappa角测量仪测量受试者双眼水平和垂直Kappa角,每个受试者测量3次移动距离,取平均值,计算水平和垂直的Kappa角.采用IOLMaster测量受试者的眼轴长度、前房深度和角膜曲率半径,采用多元线性回归模型分析眼轴长度、角膜曲率、前房深度对Kappa角变化的影响. 结果 以眼轴长度（X1）、前房深度（X2）和角膜曲率半径（X3）作为自变量、水平Kappa角（Y）作为因变量建立的有效回归方程为：Y=15.554-0.587X1 ＋0.724X2 ＋0.232X3（R=0.788,R2=0.621,P=0.000）,眼轴长度与水平Kappa角呈明显负相关,差异有统计学意义（b1=-0.587,β1=-1.002,P=0.000）;前房深度与水平Kappa角呈明显正相关,差异有统计学意义（b2=0.724,β2=0.296,P=0.030）,角膜曲率半径与水平Kappa角无明显相关,差异无统计学意义（b3=-0.232,β3=-0.068,P=0.338）,剔除角膜曲率半径变量后回归方程为：Y=14.235-0.622X1＋0.824X2（R=0.786,R2=0.618,P=0.000）,眼轴长度与水平Kappa角呈负相关,差异有统计学意义（b1=-0.622,β1=-1.062,P＜0.05）;前房深度与水平Kappa角呈正相关,差异有统计学意义（b2=0.824,β2=0.337,P＜0.05）.眼轴长度、前房深度及角膜曲率半径与垂直Kappa角的回归方程为：Y=0.492-0.020X1＋0.038X2＋0.089X3,该回归方程中的自变量与因变量呈弱相关�
Background Angle Kappa is the angle between the pupillary axis and visual axis,and it is a major consideration in corneal refractive surgery and strabismic surgery.Researches showed that age and refractive status affect angle Kappa value,and additionally,the measuring results of angle Kappa are associated with instruments.Objective This study was to investigate and weight the influences of axial length,anterior chamber depth and corneal curvature to angle Kappa.Methods A cross-sectional study was designed.Fifty health volunteers were included from Dec 2009 to Aug 2010,with the age of 18-38 years and average diopter of-1.0 D and best corrected visual acuity of 1.0.The horizontal and vertical angle Kappa was binocular measured with a testing machine designed by laboratory of School of Optometry ＆amp; Ophthalmology Wenzhou Medical University.IOLMaster was employed to measure the ocular axial length,anterior chamber depth and corneal curvature radius.A multiple linear regression model was established to analyze the influences of axial length,anterior chamber depth and corneal curvature radius to angle Kappa.Results An efficacious regression equation was established as Y =15.554-0.587X1＋0.724X2＋ 0.232X3 with the independent variables as axial length（X1）,anterior chamber depth （X2）,corneal curvature （X3） and dependent variable as horizontal angle Kappa （Y） （R =0.788,R2 =0.621,P =0.000）.Horizontal angle Kappa showed a negative correlation with axial length （b1 =-0.587,β1 =-1.002,P =0.000） and a positive correlation with anterior chamber depth （b2 =0.724,β32 =0.296,P =0.030）.No significant correlation was found between corneal curvature radius and horizontal angle Kappa （b3 =-0.232,β3 =-0.068,P=0.338）.A new regression equation was Y =14.235-0.622X1 ＋ 0.824X2 after removed the corneal curvature variable （R =0.786,R2=0.618,P =0.000）,with a negative correlation between horizontal angle Kappa and axial length （b1 =-0.622,β1 =-1.062,P〈0.05） or positive correlation between
出处
《中华实验眼科杂志》
CAS
CSCD
北大核心
2014年第5期425-429,共5页
Chinese Journal Of Experimental Ophthalmology
关键词
KAPPA角
眼轴长度
前房深度
角膜曲率
Angle Kappa
Axial length
Anterior chamber depth
Corneal curvature
