摘要
目的:探讨VEGF-C和Syk在乳腺癌中的表达与淋巴结转移的关系。方法:应用免疫组织化学方法,检测40例乳腺浸润性导管癌、10例乳腺纤维腺瘤、10例正常乳腺组织Syk和VEGF-C的表达,分析其与淋巴结转移的关系。结果:VEGF-C在正常乳腺组织、乳腺纤维腺瘤、乳腺癌中的阳性表达率分别为0%(0/10),30.0%(3/10),77.5%(31/40);Syk在正常乳腺组织、乳腺纤维腺瘤、乳腺癌中的阳性表达率分别为100%(10/10),100%(10/10),37.5%(15/40)。VEGF-C表达与肿瘤直径、组织学分级无显著相关(P>0.05;P>0.05),与淋巴结转移呈显著相关(P<0.05);Syk表达与肿瘤直径、组织学分级无显著相关(P>0.05;P>0.05),与淋巴结转移呈显著相关(P<0.05);Syk与VEGF-C间差异有统计学意义(P<0.05)。结论:Syk和VEGF-C参与了乳腺癌的淋巴道浸润、转移,可能是判断预后的重要指标。
Objective：To explore the relationship of Syk and VEGF-C expression in breast cancer with lymph node metastasis . Methods：The expression of Syk and VEGF-C in 40 cases of breast cancer were determined using immunohistochemistry assay .Then, the positive rates of Syk and VEGF-C were compared with lymph node metastasis .Results：The expression rate of VEGF-C and Syk in breast cancer was respectively 77.5%（31/40）, 37.5%（15/40）.VEGF-C protein expression was not significant related with the tumor diameter （P〉0.05） and histological grade （P〉0.05）, but was significantly associated with lymph node metastasis （P〈0.05）.Syk protein expression was not significant related with tumor diameter （P〉0.05） and the histological grade（P〉0.05）, and was associated with lymph node metastasis （P〈0.05）.The difference of Syk and VEGF-C had statistics significance（P〈0.05）.Con-clusion：Syk and VEGF-C involved in the lymphatic invasion and metastasis , may be an important indicator of prognosis .
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2014年第5期681-683,共3页
Chinese Journal of Immunology
