摘要
鲍曼不动杆菌是临床常见的条件致病菌,广泛分布于医院环境中,常导致患者出现血流、呼吸道、泌尿生殖道及中枢神经系统感染。作为一种新型的四环素类抗菌药物,替加环素对鲍曼不动杆菌尤其是泛耐药鲍曼不动杆菌具有很好的疗效,但其耐药性也日趋严重。流行病学研究发现,鲍曼不动杆菌对替加环素的耐药性呈现出显著的地区性差异。相关基础研究表明,其耐药机制主要与AdeABC外排泵系统的过表达有关。结合近期的研究结果,本文就耐替加环素鲍曼不动杆菌的流行病学现状和耐药机制进行简要综述。
Acinetobacter baumannii is a common opportunistic pathogen, which is widely distributed in the hospital settings, and often results in bloodstream infections, hospital-acquired pneumonia, UTI and meningitis among patients. As a novel class of tetracycline, tigecycline has shown high antimicrobial activity against Acinetobacter baumannii, especially extensively drug-resistant Acinetobacter baumannii, while its resistance to tigecycline was posing a growing problem over the past few years. Epidemiological studies revealed that the prevalence of tigecycline-resistant Acinetobacter baumannii differed significantly through different areas. Futher studies indicated that the overexpression of resistance-nodulation-division （RND）-type efflux system, AdeABC, plays a key role in Acinetobacter baumannii＇s resistance to tigecycline. For optimization of clinical management of Acinetobacter baumannii infection, the prevalence and underlying mechanisms of tigecycline-resistant Acinetobacter baumannii were briefly reviewed.
出处
《国外医药（抗生素分册）》
CAS
2014年第3期97-102,共6页
World Notes on Antibiotics
关键词
鲍曼不动杆菌
替加环素
流行病学
耐药机制
Acinetobacter baumannii
tigecycline
epidemiology
resistance mechanism
