摘要
目的探讨机采血小板体外解聚不良原因和应对措施，确保血小板的正常生理活性，保证临床输注效果。方法调查2011年3月～2013年2月血小板采集后出现解聚不良情况进行统计分析，评估向血小板制品中加入适量抗凝剂对血小板解聚的影响。结果38名单呆献血者出现血小板解聚不良，其中2名献血者多次捐献血小板都出现解聚不良，16名首次献机采血小板出现解聚不良，余20名重复献血者，多次献血出现1次解聚不良的情况。对解聚不良血小板制品中加入适量抗凝剂能有效改善解聚不良。结论血小板解聚不良可发生在首次和多次献血者中，解聚不良因素中献血者相关因素比例最高，采取针对性措施能有效减少体外解聚不良情况的发生。当遇到血小板解聚不良，加入适量抗凝剂能及时改善解聚不良，保证血小板的临床使用效果。
Objective To investigate the causes of poor deaggregation of in vitro apheresis platelets and its coping measures , to ensure the normal physiological activity of platelets and the clinical infusion effect. Methods During March 2011 to February 2013 ,poor deaggregation of in vitro apheresis platelets was statistical analyzed. The effect of adding a proper amount of anticoagulants into platelet products on deaggrcgation was analyzed. Results Poor deaggregation of apheresis platelets appeared in 38 donors,including 2 repeat donors who had poor deaggrcgation in each donation, more than 20 repeat donors who had one poor deaggregation and 16 first time donors. Adding a proper amount of anticoagulant could effectively improve deaggregation. Conclusion Poor deaggregation of apheresis platelet can occur in the first time donors and repeat donors. Factors related to donors account for the highest proportion of factors associated with poor deaggregation. Targeted measures can effectively reduce the occurrence of poor deaggregation. When platelet poor deaggregation happens, adding a proper amount of anti- coagulant can promptly improve it and ensure the clinical effect of platelet.
出处
《中国输血杂志》
CAS
CSCD
北大核心
2014年第4期433-434,共2页
Chinese Journal of Blood Transfusion
关键词
机采血小板
血小板解聚不良
apheresis platelets
poor deaggregation of platelet
