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环孢素联合达那唑治疗难治性特发性血小板减少性紫癜的疗效观察 被引量:9

The curative observation of cyclosporine combined with danazol in the treatment of refractory idiopathic thrombocytopenic purpura
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摘要 目的探讨环孢素A(CSA)联合达那唑治疗难治性特发性血小板减少性紫癜(ITP)的临床效果。方法 45例难治性ITP患者随机分为两组,对照组(n=21例)给予长春新碱或环磷酰胺治疗,观察组(n=24例)给予CSA联合达那唑治疗,两组疗程均为3个月。治疗后比较两组疗效及不良反应发生率。结果观察组治疗总有效率(79.2%)明显高于对照组(66.7%),差异有统计学意义(P<0.05);两组治疗期间不良反应发生率比较(45.8%vs.47.6%)无显著差异性(P>0.05)。结论 CSA联合达那唑治疗难治性ITP疗效显著,安全可靠,值得临床推广应用。 Objective To investigate the clinical effect of cyclosporine A(CSA)combined with danazol in the treatment of refractory idi-opathic thrombocytopenic purpura(ITP). Methods 45 patients with refractory ITP were randomly divided into two groups,the control group(n= 21 cases)was treated with vincristine and cyclophosphamide,and the observation group(n = 24 cases)was treated with CSA combined with danazol. Two groups were treated for 3 months. The clinical effect and the rate of adverse reaction of two groups were compared. Results The to-tal efficiency of the observation group(79. 2% )was significantly higher than that of the control group(66. 7% )( P〈 0. 05);and there was no significant difference between the rate of adverse reaction in two groups during the treatment(45. 8% ,47. 6% )( P〈 0. 05). Conclusion The treatment of CSA combined with danazol for refractory ITP had a significantly effect,safe and reliable. It was worthy of clinical application.
作者 刘传才
出处 《临床和实验医学杂志》 2014年第9期724-725,共2页 Journal of Clinical and Experimental Medicine
关键词 特发性血小板减少性紫癜 环孢素 A 达那唑 Idiopathic thrombocytopenic purpura Cyclosporine A Danazol
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