摘要
目的观察小剂量环孢素A治疗难治性特发性血小板减少性紫癜(ITP)的临床疗效。方法将63例难治性ITP患者随机分为环孢素A组和长春新碱组。环孢素A组:环孢素A 4～6 mg/(kg.d)口服,分2次口服,疗程共3个月。长春新碱组:长春新碱1.5 mg/m2静脉注射,每周1次,共6次。结果环孢素A组总有效率为84.4%,明显高于长春新碱的54.8%(P<0.05)。结论小剂量的环孢素A治疗难治ITP效果较显著,无严重不良反应,目前是难治性ITP的一种有效、安全可行的治疗方法,值得进一步深入研究应用。
Objective： To evaluate the efficacy of cyclosporin A in the treatment of refractory idiopathic thrombocytopenic purpura.Methods： Sixty-three patients with refractory idiopathic were treated with cyclosporin A or Vincristine.In the cyclosporin A group,Cyclosporin A 4 ～ 6 mg /（kg.d） was given in divided doses for three months;in the Vincristine group,Vincristine was given 1.5mg / m2 each week for six weeks.Results： The effective rate was 84.4% in cyclosporin A group,while it was 54.8% in Vincristine group,and the difference was significant.Conclusion： Cyclosporin A is more effective than Vincristine in the treatment of refractory idiopathic thrombocytopenic purpura,and deserves the clinical expansion.
出处
《泰山医学院学报》
CAS
2013年第4期281-283,共3页
Journal of Taishan Medical College
