摘要
目的探讨肥胖对新诊断2型糖尿病(T2DM)患者血清β抑制素2及胰岛素抵抗的影响。方法选取2012年6—12月在本院内分泌科就诊的新诊断T2DM肥胖患者30例(T2DM肥胖组,BMI≥28 kg/m2)、新诊断T2DM非肥胖患者30例(T2DM非肥胖组,BMI<24 kg/m2)、体检健康者30例(对照组)。检测3组受检者空腹血清β抑制素2水平及其他实验室检查指标,计算胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-β)和胰岛素敏感性指数(ISI)。多组间均数比较采用方差分析,β抑制素2相关因素分析采用Spearman相关分析。结果对照组、T2DM非肥胖组、T2DM肥胖组血清β抑制素2水平依次降低〔(341.5±14.4)、(332.4±17.7)、(319.1±15.8)ng/L,P<0.05〕。BMI与HOMA-IR呈正相关,与ISI呈负相关(P<0.01);β抑制素2与BMI、HOMA-IR呈负相关,与ISI呈正相关(P<0.01)。结论肥胖是影响T2DM患者血清β抑制素2水平及胰岛素抵抗的重要因素;肥胖的T2DM患者血清β抑制素2水平较体质量适中的T2DM患者降低,且胰岛素抵抗进一步加剧。
Objective To explore the effect of obesity on serum β- arrestin 2 and insulin resistance （IR） in newly diagnosed type 2 diabetes （T2DM） patients. Methods In the Department of Endocrinology, the First Affiliated Hospital of Jiamusi University from June to December 2012, 30 obese patients newly diagnosed as T2DM （obese group, BMI ≥28 kg/m^2） , 30 non - obese patients newly diagnosed as T2DM （ non - obese group, BMI 〈 24 kg/m^2 ）, 30 healthy subjects （ control group） were enrolled in this study. Fasting serum β - arrestin 2 level and other laboratory examination indicators were determined, insulin resistance index （ HOMA - IR）, pancreatic β- cell function index （ HOMA - β）, insulin sensitivity index （ISI） were calculated. Variance analysis was used to compare means, Spearman correlation analysis was used to analyze β - arrestin 2 related factors. Results The levels of β - arrestin 2 reduced in groups control, obese, non - obese （ （ 341.5 ±14. 4） , （332.4 ± 17.7）, （ 319. 1 ±15.8 ） ng/L, P 〈 0. 051. BMI was positively correlated with HOMA - IR, negatively with ISI （ P 〈 0. 01 ）. Level of β - arrestin 2 was negatively correlated with BMI, HOMA - IR, positively with ISI （ P 〈 0. 01 ）. Conclusion Obesity is an important factor influencing β - arrestin 2 level and IR in T2DM patients. The level of β - arrestin 2 is lower in obese T2DM patients than in non - obese ones, further exacerbating IR.
出处
《中国全科医学》
CAS
CSCD
北大核心
2014年第11期1238-1240,共3页
Chinese General Practice
基金
黑龙江省教育厅科学技术研究项目(12521566)
关键词
糖尿病
2型
肥胖
β抑制素2
胰岛素抵抗
Diabetes mellitus, type 2
Obesity
β - arrestin 2
Insulin resistance
