摘要
目的 综合分析全基因组关联性研究识别的rs961253基因多态性与结直肠癌易感性的关系.方法 以广义OR（generalized OR,ORG）及等位基因比较（A/C）的OR为效应指标.结果 最终纳入文献7篇,包含3 3561例结直肠癌病例及35 790名对照.研究间存在异质性,故采用随机效应模型合并效应值.A/C合并OR值为1.13（95％CI=1.09-1.17）;合并ORG值为1.16（95％CI=1.11 ～ 1.21）.Meta同归分析发现异质性主要来源为研究对象的种族和对照来源,经分层后,异质性有效降低,且rs961253仍与结直肠癌关联.敏感性分析表明研究结果稳定 结论 rs961253基因多态性与结直肠癌遗传易感性相关,但背后的生物学机制仍有待研究证实.
Objective To investigate the association between rs961253 polymorphism and susceptibility of colorectal cancer through a Meta-analysis.Methods Generalized OR （ORe.） and OR of allelic contrast （A versus C ） were applied as effect estimates assessing the association of rs961253. Results A total of 7 publications,with 33 561 cases and 35 790 controls,were finally included.Due to evidence of heterogeneity, a random-effect model was applied to combined estimates.The pooled OR of allelic contrast was of 1.13 （95% CI = 1.09-1.17 ）, and the pooled ORc was of 1.16 （95% CI = 1.11- 1.21 ）. In Meta-regression analysis, the heterogeneity can be largely explained by population ethnieity and control sources. After stratified by these two factors, heterogeneity was significantly decreased, and significant association of rs961253 remained in all subgroups.Sensitivity analysis suggested the robust stability of the current results. Conclusions rs961253 polymorphism is significantly associated with susceptibility of coloreetal cancer. Nevertheless,further studies are warranted to depict the underlying biological mechanism.
出处
《广东药学院学报》
CAS
2014年第2期232-237,240,共7页
Academic Journal of Guangdong College of Pharmacy
基金
广东省医学科研基金(B2012176)
广东高校优秀青年创新人才培养计划项目(2012LYM_0082)
