摘要
目的研究复发性外阴阴道假丝酵母菌病的主要病原菌分布及耐药性,指导临床合理应用抗菌药物治疗阴道假丝酵母菌病。方法回顾性分析医院2011年1月-2012年12月就诊的复发性外阴阴道假丝酵母菌病患者108例,取得阴道分泌物进行病原菌培养,并对其进行药敏分析,所有数据采用SPSS13.0进行统计分析。结果 108例复发性外阴阴道假丝酵母菌病患者中共分离出病原菌116株,其中8例患者合并≥2种病原菌;116株病原菌中白色假丝酵母菌72株占62.07%、克柔假丝酵母菌24株占20.69%、光滑假丝酵母菌13株占11.21%、热带假丝酵母菌7株占6.03%;白色假丝酵母菌对伊曲康唑和咪康唑的耐药率较低分别为4.17%和8.33%,克柔假丝酵母菌对伊曲康唑和咪康唑的耐药率较低分别为4.17%和8.33%,光滑假丝酵母菌对伊曲康唑和克霉唑的耐药率均为0。结论临床治疗复发性外阴阴道假丝酵母菌病时应先进行细菌培养鉴定,并根据药敏试验结果进行有针对性的抗真菌药物治疗。
OBJECTIVE To study the distribution and drug resistance rate of the main pathogens causing recurrent VVA so as to guide the rational use of antibiotics for treating VVA in clinical practice.METHODS Totally 108 cases of recurrent VVA patients who went to the hospital for diagnosis from Jan 2011to Dec 2012were retrospectively analyzed;vaginal secretion of them were obtained to perform pathogen culture and perform drug sensitivity analysis;all the data were statistically analyzed with SPSS 13.0.RESULTS A total of 116strains of pathogens were isolated from 108cases of recurrent VVA patients,with 8patients infected with 2or more types of pathogens.72 strains of Candida albicans accounted for 62.07%,24 strains of Candidakruseiaccounted for 20.69%,13strains of Candida glabrada accounted for 11.21%,and 7strains of Candida tropicalis accounted for 6.03% among the 116strains of pathogens.The resistance rates of C.albicansto itraconazole and miconazole were low,4.17% and 8.33% respectively.The resistance rates of C.krusei to itraconazole and miconazole were low,4.17% and 8.33% respectively.Both the drug resistance rates of C.glabratato itraconazole and clotrimazole were 0.CONCLUSIONBacterial culture and identification should be performed first during the clinical treatment of recurrent VVA,and it is necessary to perform targeted antifungal drug treatment as per drug sensitivity test results.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2014年第9期2133-2134,2137,共3页
Chinese Journal of Nosocomiology
基金
齐齐哈尔市科学技术计划基金资助项目(QQHE20120312)
关键词
外阴阴道假丝酵母菌病
病原菌
耐药性
Recurrent Vulvovaginal Candidiasis
Pathogens
Drug resistance
