摘要
溃疡性结肠炎为一种难治性、易复发且有癌变倾向的炎症性肠病。近年来溃疡性结肠炎相关性结直肠癌(ulcerative colitis-associated colorectal cancer,UC-CRC)发病率呈上升趋势,其病因和确切的发病机制尚未明确,UC-CRC是溃疡性结肠炎最为严重的并发症。目前,多数学者认为此病是多环节、多因素、多基因改变综合作用的结果,被WHO列为现代难治性疾病之一。本文对溃疡性结肠炎相关性结直肠癌的危险因素、发病机制以及预防作一综述。
Ulcerative colitis is a kind of inflammatory bowel disease that is difficult to treat,easy to recur and prone to become malignant. The morbidity of ulcerative colitis - associated colorectal cancer（UC - CRC） has increased in re- cent years while the precise etiology and pathogenesis remains unknown, it is the worst complication of ulcerative coli- tis （UC）. At present, most scholars believe that the disease is the result of the combined effect of more links, more fac- tors and many genetic changes,by the WHO as a modern one of refractory diseases. This article reviewed these risk factors,pathogenesis and prevention about the etiology of ulcerative colitis - associated colorectal cancer.
出处
《现代肿瘤医学》
CAS
2014年第3期720-722,共3页
Journal of Modern Oncology
关键词
溃疡性结肠炎相关性结直肠癌
危险因素
发病机制
预防
ulcerative colitis - associated colorectal cancer
risk factors
mechanisms
prevention
