YB-1与肝纤维化及肝癌关系的研究进展
被引量：1
摘要
Y-box结合蛋白-1(YB-1)在肝纤维化中起着重要的抑制作用。细胞因子Hsc025可与YB-1蛋白C端的氨基酸序列结合,引导后者的核转位,从而阻断TGF-β/Smad信号转导而抑制胶原基因表达;干扰素-γ(IFN-γ)也可通过YB-1负调控胶原基因表达。同时,研究发现有多种肿瘤高表达YB-1。在肝细胞癌中,YB-1与血管侵袭、肿瘤转移、疾病预后等相关,又因其特异性强,有望作为肿瘤检测的指标。
出处
《国际消化病杂志》
CAS
2014年第1期42-43,共2页
International Journal of Digestive Diseases
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