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非小细胞肺癌中YB-1蛋白的表达及临床意义 被引量：2

Expression of YB-1 Protein in Patients with NSCLC and its Clinical Significance
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摘要 [目的]探讨YB-1蛋白在非小细胞肺癌(NSCLC)中的表达,及其与NSCLC发生及生物学行为的相关性。[方法]采用链霉菌抗生物素蛋白—过氧化酶免疫组织化学方法检测28例正常肺组织和63例NSCLC患者肺癌组织标本中YB-1蛋白的表达情况,并分析其与临床病理特征的关系。[结果]YB-1蛋白在正常肺组织细胞质和细胞核中均为阴性表达;在63例NSCLC患者中,所有的细胞质都有YB-1蛋白表达;而细胞核只有31例表达,阳性率为49.2%。YB-1蛋白表达与病理类型、临床分期及淋巴结转移相关(P<0.05),而与分化程度、性别及年龄无相关性(P>0.05)。[结论]YB-1蛋白在NSCLC的发生、发展中起重要作用,检测YB-1蛋白有助于对NSCLC患者的诊断、淋巴结转移和预后判断。
作者 孙云晖 黄燕 阎红娥 鲍文华
机构地区 黑龙江佳木斯大学附属第一医院
出处 《肿瘤学杂志》 CAS 2009年第8期719-721,共3页 Journal of Chinese Oncology
关键词 非小细胞肺 YB-1蛋白 免疫组织化学
分类号 R734.2 [医药卫生—肿瘤]
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参考文献6

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同被引文献17

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肿瘤学杂志
2009年 第8期

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