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沙利度胺抗肿瘤作用及其治疗卵巢癌的研究进展 被引量:1

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摘要 反应停(沙利度胺,thalidomide)是1953年西德Chemie Grunenthal公司在开发治疗变态反应的抗组胺新药物时合成[1],后来用于治疗孕妇早期的恶心和呕吐[2],且动物实验显示无毒性反应.但短短几年即发现许多在怀孕前3个月服用反应停的孕妇产出四肢不全、兔唇呈海豹状,其他还包括脊柱神经缺损、腭裂、耳与腹部脏器异常的畸形新生儿.
出处 《实用医药杂志》 2014年第4期365-367,共3页 Practical Journal of Medicine & Pharmacy
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  • 1Thomas Deborah A,Kantarjian Hagop M. Current role of tha- lidomide in cancer treatment[J]. Current Opinion in Oncology, 2000,12(6) :564-572. 被引量:1
  • 2Kanbayashi T,Shimizu T,Takahashi Y,et al. Thalidomide in- creases both REM and stage 3- 4 sleep in human adults: a preliminary study [ J ]. Sleep, 1999,22 (2) : 113-115. 被引量:1
  • 3Mellin GW,Katzenstein M. The saga of thalidomide (concluded): neuropathy to embryopathy, with case reports of congenital anomalies[J]. N Engl J Med, 1962,267(12) : 1238-1244. 被引量:1
  • 4Huaghes S,Nainggolan L. Product sin1997: Successes, setback sandshocksin drug development[J].Scrip Magazine, 1998,10(1), 50-89. 被引量:1
  • 5Myoung H,Hong SD,Kim YY,et al.Evaluation of the antitumorand anti-angiogenic effect of Paclitaxel and thalidomide on the xenotransplanted oral squamous cell carcinoma[J].Cancer Lett, 2001,163(2) : 191-200. 被引量:1
  • 6Kotoh T,Dhar DK, Masunaga R,et al.Antiangiogenic therapy of human esophageal cancers with thalidomide in nude mice[J]. Surgery, 1999,125 ( 5 ) : 536-544. 被引量:1
  • 7Meyring M,Muhlenbrock C,Blaschke G. Investigation of the stereoselective in vitro biotransformation of thalidomide using a dual cyclodextrin system in capillary electrophoresis[J]. Elec- trophoresis, 2000,21 ( 15 ) : 3270-9. 被引量:1
  • 8D'Amato RJ, Loughnan MS, Flynn E, et al. Thalidomide is anin- hibitory of angiogenesis[J]. Proc Natl Acad Sci USA, 1991, 91 (24) :4082. 被引量:1
  • 9Folkman J, Shing Y. What is angiogenesis? [J]. J Biol Chem, 1992, (267) : 10931. 被引量:1
  • 10Frank ME, Macpherson GR,Figg WD. Thalidomide[J]. Lancet, 2004,363(9423) : 1802-1811. 被引量:1

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