摘要
以7-ACA为原料,通过与N-甲氧亚氨基呋喃乙酰氯缩合、3位水解、然后与氯磺酰异氰酸酯缩合水解得头孢呋辛酸,在与氯磺酰异氰酸酯的缩合反应过程中,用乙酸丁酯作为反应媒介具有操作简单、产品收率高等特点,适合于工业化生产。
7-ACA was condensated with SMIF-CL,hydrolyzed of 3-position and then reacted with another reagent CSI to finish the carbamoylation reaction ,and cefuroxime acid was obtained.The yield was improved and the proce-dure was simplified when n-Butyl acetate was used as solvent in the process ,so n-Butyl acetate can be applied to the large-scale preparation of cefuroxime acid.
出处
《海峡药学》
2014年第4期136-137,共2页
Strait Pharmaceutical Journal
关键词
头孢呋辛
合成
溶剂
7-ACA
7-ACA
Cefuroxime
Synthesis
Solvent
