摘要
目的:研究Dickkopf-1和GATA-6蛋白在喉癌组织中的表达,探讨二者在喉癌发生、发展中的作用及二者的相关性。方法:应用免疫组织化学方法(SP法)检测48例喉癌组织及48例相应癌旁组织、20例非喉癌患者喉部正常黏膜组织中Dickkopf-1和GATA-6蛋白的表达情况。结果:①Dickkopf-1蛋白在喉癌组织中的阳性表达率明显低于癌旁组织和正常喉部黏膜组织(P<0.05);②GATA-6蛋白在喉癌组织中的阳性表达率明显高于癌旁组织和正常喉部黏膜组织(P<0.05);③Dickkopf-1和GATA-6蛋白在喉癌组织中的表达与喉癌淋巴结转移、临床分期、病理分级有相关性(P<0.05);④喉癌组织中Dickkopf-1蛋白表达和GATA-6蛋白表达呈负相关(r=-0.490,P<0.01)。结论:Dickkopf-1和GATA-6蛋白的表达与喉癌的发生、发展有关。
Objective.. To investigate the expression of Dickkopf-1 and GATA-6 in laryngeal carcinoma and to discuss their relevance and the roles in carcinogenesis and development of laryngeal carcinoma. Method.. Immunohistochemical technique was used to detect the expression of Dickkopf-1 and GATA-6 protein in 48 tissues of laryngeal carcinoma, 48 para-carcinoma tissues and 20 normal laryngeal mucosal tissues. Result： ①The expression of Dick- kopf-1 protein in laryngeal cancer is significantly lower than in para-carcinoma tissues and normal laryngeal mucosa tissues （P〈0.05）.②The expression of GATA-6 protein in laryngeal cancer is significantly higher than in paracarcinoma tissues and normal laryngeal mucosa tissues （P〈0.05）. ③The expression of Dickkopf-1 and GATA-6 protein in laryngeal cancer is correlated with lymph node metastasis, clinical stage, histological grade （P〈0.05）. ④The expression of Dickkopf-1 and GATA-6 are negatively correlated in laryngeal cancer. Conclusion：The expres- sion of Dickkopf-1 and GATA-6 may contribute to the carcinogenesis and development of laryngeal carcinoma.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
北大核心
2014年第9期643-646,共4页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
