摘要
总结近期国内外有关miRNA在乳腺癌化疗耐药中作用的研究进展。应用Pubmed和CNKI期刊全文数据库检索系统以"miRNA、乳腺癌和化疗耐药"为关键词,检索2000年1月至2012年10月有关在乳腺癌化疗耐药中作用的文献。从乳腺癌化疗耐药入手,阐述乳腺癌化疗耐药的特点、机制,并着重对miRNA在乳腺癌化疗耐药中的作用进行分析。miRNA通过多种途径参与乳腺癌的化疗耐药。本文具体综述了一些以不同机制参与肿瘤耐药的miRNA,及其具体参与耐药的途径。探讨了血清miRNA作为肿瘤标记物的潜在临床利用性。结论:深入研究血清miRNA在乳腺癌耐药中的作用和机制,必将为乳腺癌的靶向治疗掀起一个新的篇章。
This study aimed to review the research progress on the contribution of microRNA （miRNA） to the chemotherapy re- sistance of breast cancer. With ＂miRNA,＂ ＂breast cancer,＂ and ＂chemotherapy resistance＂ as key words, the literature was searched in Pubmed and CNKI databases between 01-2000 and 10-10-2012. We described the characteristics and mechanisms of breast cancer che- motherapy resistance and focused on the contribution of miRNAs in the chemotherapy resistance of breast cancer. MiRNA participate in chemotherapy resistance of breast cancer through different ways. This article summarizes different miRNAs that participate in che- motherapy resistance and identifies their specific pathways in drug resistance. The potential clinical utilization of the serum miRNA as a tumor marker is also discussed. Further research on the effect and mechanism of serum microRNA in chemotherapy resistance will bring a new chapter in the targeted therapy of breast cancer.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2014年第8期538-541,共4页
Chinese Journal of Clinical Oncology
基金
辽宁省科学技术计划项目(编号:2012225016)资助~~
关键词
乳腺癌
化疗耐药
MIRNA
breast cancer, chemotherapy resistance, MiRNA
