摘要
目的分析过敏性紫癜（HSP）的流行病学特点、临床特征、结果及预后，进一步指导临床实践。方法对2001年1月-2006年12月中国医科大学附属第一医院收治的695例过敏性紫癜患者的临床资料进行回顾性分析。结果共入选695例过敏性紫癜患者，男399例（57．41％），女296例（42．59％），男女之比为1．35。本病秋冬季节常见，上呼吸道感染是其常见诱因。均有皮疹表现，且多累及下肢（97．44％），胃肠为50．50％，肾脏为42．30％，关节为31．94％。儿童患者胃肠症状和关节症状常见，而肾脏累及多发生于成人。实验室异常包括IgA和IgW水平增高，补体C3和c4水平降低，IgM型支原体抗体阳性。平均住院时间为（9．984-4．66）d，成人的平均住院时间长于儿童。结论就本研究结果而言过敏性紫癜多发于7。13岁男童。成人和儿童过敏性紫癜在临床特征方面有所不同，儿童过敏性紫癜患者应特别注意观察其关节和胃肠症状，成人过敏性紫癜患者应特别注意其肾脏体征。
Objective To examine epidemiological, clinical, and outcome of patients affected with Henoch-schonlein purpura（HSP） and provide reference to clinical work. Methods Cases discharged with a diagnosis of HSP were collected by reviewing medical charts. Then we took SPSS 13.0 to analyze if the characteristics above had statistical differences. Results The study group consisted of 695 cases, 399 male （57.41%） and 296 female （42. 59% ）, and the ratio of male to female was 1.35. The disease was more common in autumn and winter, often induced by an upper respiratory tract infection. The lesions were present in all cases, and mostly located on the lower legs （97.44%）, abdominal involvement in 50. 50%, renal involvement in 42. 30%, arthritis/arthralgias in 31.94%. Abdominal involvement and joint manifestation were often seen in children, while renal manifestation was common in adults. Laboratory abnormalities mainly included hyper- IgA and IgE, low C3 and C4, positive IgM antibodies for mycoplasma pneumoniae. The mean hospitalization time was （9. 98 ＋ 4. 66） day. The mean hospitalization time of adults was longer than children. Conclusion For this study,HSP is common in 7 - 13 years old boy. There were different clinical features in adult and children HSP. We should take more attention to children with abdominal involvement and joint manifestation and adults with renal manifestation.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2014年第5期482-484,共3页
The Chinese Journal of Dermatovenereology
关键词
过敏性紫癜
流行病学
临床分析
Henoeh-Sehonlein purpura
Epidemiology
Clinical manifestation
