摘要
目的研究苦瓜茎叶醋酸乙酯部位的化学成分,为进一步开发利用苦瓜茎叶提供依据。方法采用反复硅胶柱色谱、反相ODS柱色谱、Sephadex LH-20等柱色谱进行分离纯化,并根据波谱数据鉴定化合物的结构。结果分离得到3种苦瓜三萜,分别鉴定为苦瓜素I(1)、kuguacin N(2)、3,7-二羟基-23(R)-乙氧基-19-醛基-5,24-二烯醇(3)。结论化合物3为新化合物,命名为23-乙基苦瓜素I。
Objective To investigate the chemical constituents in ethyl acetate fraction from the fresh vines and leaves of Momordica charantia, so as to provide a basis for the further development and utilization. Methods Chemical constituents were isolated and purified by chromatography on silica gel and octadecylsilanized （ODS） silica gel columns, and the structures were identified on the basis of spectroscopic data. Results Three cucurbitane triterpcnoids were isolated and they were identified as momordicine I （1）, kuguacin N （2）, and 3,7-dihydroxycucurbita-23（R）-ethoxy-5,24-dien-19-al （3）. Conclusion Compound 3 is a new compound named 23-ethyl momordicine 1.
出处
《现代药物与临床》
CAS
2014年第4期346-348,共3页
Drugs & Clinic
