摘要
目的考察4种不同型号直压甘露醇M200、M100、C、D的粉体学性能。方法测定4种甘露醇的休止角、模型药物的粒度、粒度分布、比表面积等指标以及电镜扫描图。选择模型药物考察甘露醇的容纳性,评价其在粉末直接压片工艺中的应用。结果 4种型号甘露醇均具有良好的流动性,且对模型药物有很好的容纳性。结论甘露醇是良好的直压工艺的填充剂,不同型号的甘露醇对模型药物的容纳性有一定差异。
Objective To Investigate the powder properties of four different types of direct pressure mannitol （mannitol M200, M 100, C, and D）. Methods The angle of repose of four mannitols, particle sizes of model drugs, the distribution of particle size, and specific surface area were determined, as well as the electron microscope scan was studied. The containment of the mannitols by choosing a model drug was examined to evaluate the applications in the powder direct pressure process. Results All of the four models of mannitols had the good mobility and good containment on model drugs. Conclusions Mannitol is a good filler in the direct pressure process and different types of mannitols have different containment in the model drug.
出处
《现代药物与临床》
CAS
2014年第4期342-345,共4页
Drugs & Clinic
关键词
甘露醇
休止角
粒度分布
电镜扫描
比表面积
mannitol
angle of repose
distribution of particle size
electron microscope scan
surface area
