摘要
目的 :研究氟康唑β-环糊精包合物的制备工艺、含量测定及溶出度。方法 :用共沉淀法及超声法制备氟康唑 β-环糊精包合物 ,用紫外分光光度法测定其包合物含量及累积溶出百分率。结果 :经紫外扫描和电镜扫描确定 ,氟康唑与β-环糊精在两种制备工艺条件下均能形成包合物 ,包合物含药量分别为(11 34±0 77) %、(11 23±0 24) % ,包合物溶出度符合《中国药典》固体制剂溶出度规定。结论
OBJECTIVE:To study the preparation technic and determination of the content and dissolubility of the fluconazole-β-cyclodextrin inclusion complex(FCIC) METHODS:The FCIC was prepared by coprecipitation method and ultr_asonic method The content and percentage of the accumulated dissolubility of FCIC were determined by UV-spectrophotometry RESULTS:Fluconazole and β-cyclodextrin could form inclusion complex through either preparation technology The contents of fluconazole in the complex were(11 34±0 77)% and(11 23±0 24)% respectively The dissolubility met the standard in CP CONCLUSION:Stable complex could be formed between fluconazole and β-cyclodextrin
出处
《中国药房》
CAS
CSCD
2003年第7期404-406,共3页
China Pharmacy
关键词
氟康唑
Β-环糊精包合物
唑类抗真菌药物
制备工艺
含量测定
溶出度
fluconazole-β-cyclodextrin inclusion complex
preparation
determination of content
dissolubility
identification
