摘要
目的 探讨妊娠高血压综合征 (妊高征 )患者血浆P 选择素和一氧化氮 (nitricoxide,NO)含量的变化及其在妊高征发病中的意义。方法 采用酶联免疫吸附法测定 36例妊高征患者 (妊高征组 ,其中轻度妊高征患者 11例 ,中重度妊高征患者 2 5例 )、18例正常晚孕妇女 (正常晚孕组 )和 19例正常非孕妇女 (正常非孕组 )血浆P 选择素含量。用镀铜镉还原法测定血浆中代表NO水平的亚硝酸盐及硝酸盐 (nitriteandnitrate ,NO2 -/NO3-)含量。结果 正常晚孕组血浆P 选择素含量为 (4 8 92±15 16 ) μg/L ,正常非孕组为 (30 16± 8 42 ) μg/L ,两组比较 ,差异有极显著性 (P <0 0 0 1) ;轻度妊高征患者血浆P 选择素含量为 (4 7 33± 17 95 ) μg/L ,与正常晚孕组比较 ,差异无显著性 (P >0 0 5 ) ;中、重度妊高征患者血浆P 选择素含量为 (70 11± 17 6 5 ) μg/L ,与轻度妊高征患者及正常晚孕组比较 ,差异有极显著性 (P <0 0 1,P <0 0 0 1) ;正常晚孕组血浆NO2 -/NO3-含量为 (6 3 2 1± 14 0 2 ) μmol/L ,正常非孕组为 (5 2 17± 7 2 0 ) μmol/L ,两组比较 ,差异有极显著性 (P <0 0 1) ;妊高征组血浆NO2 -/NO3-含量为(37 71± 10 30 ) μmol/L ,显著低于正常晚孕组 (P <0 0 0 1) ;轻度妊高征患者血浆NO2
Objective To study the roles of P selectin and nitric oxide (NO) on the etiology of pregnancy induced hypertension (PIH) Methods The levels of plasma P selectin and nitrite and nitrate (NO 2 -/NO 3 -) were determined in 36 patients with PIH The data were compared with those of normal pregnant group ( n =18) and healthy non pregnant group ( n =19) The levels of plasma P selectin were measured by means of enzyme linked immunosorbent assay (ELISA) and levels of plasma NO 2 -/NO 3 - were measured by Griess reaction after the nitrate was reduced by a Cadmium reduction method Results The results showed: (1)The level of P selectin in the normal pregnant group (48 92±15 16) μg/L was higher than that in non pregnant group [(30 16± 8 42) μg/L, P <0 001] There was no significantly statistical difference in the levels of P selectin between the normal pregnant group and the mild PIH group ( P >0 05). The levels of P selectin in the moderate and severe PIH group (70 11±17 65) μg/L were higher than those in the mild PIH group [(47 33±17 95) μg/L, P <0 01] and the normal pregnant group ( P <0 001) (2)The concentration of NO 2 -/NO 3 - in normal pregnant group was higher than that in non pregnant group ( P <0 01). The concentration of NO 2 -/NO 3 - in PIH group were lower than was in normal pregnant group ( P <0 001). The NO 2 -/NO 3 - in mild group was lower than that in normal pregnant group ( P <0 001). The Plasma concentration of NO 2 -/NO 3 - in moderate and severe PIH group was lower than that of mild group ( P <0 05) (3) There was a negative correlation between the plasma concentration of P selectin and NO 2 -/NO 3 - in the PIH group Conclusion The changes of plasma levels of P selectin and NO are related to the occurrence and development of PIH
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2001年第1期12-14,共3页
Chinese Journal of Obstetrics and Gynecology
关键词
妊娠并发症
心血管
高血压
P选择素
一氧化氮
Pregnancy complications,cardiovascular
Hypertension
P-selectin
Nitric oxide
