摘要
目的:研究川芎嗪对妊娠期高血压疾病内皮细胞损伤与凝血-纤溶系统失衡的干预作用,探讨川芎嗪配伍硫酸镁治疗妊娠期高血压疾病的疗效。方法:随机选取90例孕妇,其中正常妊娠组30例;子痫前期患者60例,分为对照组、观察组。对照组给予常规硫酸镁治疗,观察组给予硫酸镁+川芎嗪治疗。分别测定正常妊娠组及对照组、观察组用药前后的vWF、D-Dimer、BPC、Fg含量。结果:①按正常妊娠组、子痫前期轻度组、子痫前期重度组顺序,各指标血浆水平逐渐升高或减低,差异有显著性。②对照组用药前后各指标水平改变差异无显著性。③观察组用药前后各指标水平改变有显著性差异。结论:川芎嗪对内皮细胞有保护作用,抑制血小板活化,调节凝血和纤溶,逆转血栓前状态;川芎嗪配伍硫酸镁是治疗妊娠期高血压疾病的综合策略。
Objective： To evaluate the intervention function of Ligustrazine in Hypertensive disorder complicating pregnancy vascular endothelial cell damage and coagulation - fibrinolysis system disequilibrium, explore the therapeutically effects of Ligustrazine compatibility MgSO4 in Hypertensive disorder complicating pregnancy. Methods： 90 pregnant women were randomly selected and divided into the group of normal pregnancy （n =30）, the preeclampsia control group （30 patients with preeclampsia） and the preeclampsia observe group （30 patients with preeclampsia） . The preeclampsia control group： to supply routine method using MgSO4. The preeclampsia observe group： to supply MgSO4and ligustrazine. The levels of vWF, D - Dimer, BPC, Fg before and after using drugs were determined in the preeclampsia control group and the preeclampsia observe group. Results： （1）The expression levels of vWF, D -Dimer, BPC, Fg in plasma in the group of normal pregnancy, the mild preeclampsia group and the severe preeclampsia group were significantly lower or higher; （2） The expression levels of vWF, D -Dimer, BPC, Fg were no significant difference in the preeclampsia control group before and after therapy; （3） The expression levels of vWF, D - Dimer, BPC, Fg were significantly difference in the preeclampsia observe group before and after therapy. Conclusion： Ligustrazine can prevent vascular endothelial cell, inhabit the activation of BPC, regulate coagulation -fibrinolysis, and reverse the prethrombofic state. Ligustrazine compatibility MgSO4 can be used to reverse Hypertensive disorder complicating pregnancy the prethrombotic state, to prevent generation and development of serious complication and improve its prognosis.
出处
《中国妇幼保健》
CAS
北大核心
2008年第18期2572-2575,共4页
Maternal and Child Health Care of China
基金
河北省衡水市科学技术研究与发展计划课题(课题编号:07025A)
关键词
妊娠期高血压疾病
血管内皮细胞损伤
凝血-纤溶系统失衡
血栓前状态
川芎嗪
Hypertensive disorder complicating pregnancy
Vascular endothelial cell （VEC） damage
Coagulation -fibrinolysis system disequilibrium
The prethrombotic state
Ligustrazine
