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绝经后2型糖尿病骨密度与肿瘤坏死因子-α、白介素-6的相关性 被引量:8

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摘要 目的:探讨绝经后2型糖尿病患者的骨密度(BMD)与TNF-α、IL-6的相关性。方法:选取绝经后女性2型糖尿病患者100例,根据BMD分3组:骨量正常组、骨量减少组和骨质疏松组。测量患者的一般临床资料、TNF-α、IL-6水平,对3组的一般临床资料及TNF-α、IL-6进行统计学分析。结果:3组的HbAlc、糖尿病病程差异无统计学意义(P>0.05);与骨量正常组比较,骨量减少组和骨质疏松组的BMI水平降低(P<0.05),TNF-α、IL-6水平升高(P<0.05),3组间钙、磷、25-羟维生素D无统计学差异,BMD与BMI呈正相关(r=0.236,P<0.05),与年龄、绝经年限、TNF-α、IL-6呈负相关(r=-0.436,-0.487,-0.527,-0.577,P<0.05)。结论:绝经后2型糖尿病患者BMD与绝经年限、TNF-α及IL-6密切相关。
出处 《实用医学杂志》 CAS 北大核心 2014年第8期1292-1293,共2页 The Journal of Practical Medicine
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参考文献8

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