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绝经后2型糖尿病患者白介素-6与腰椎、股骨颈骨密度的关系 被引量:3

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摘要 目的:探讨绝经后2型糖尿病(T2DM)患者血清白介素-6(IL-6)水平与腰椎、股骨颈骨密度(BMD)的关系。方法:采用双能X线骨密度仪测定89例绝经后T2DM患者的正位腰椎(L1~4)、左股骨颈BMD,并测定部分实验室相关指标,记录年龄、病程、绝经年龄、绝经年限及计算体重指数(BMI)等,分为骨质疏松组(OP组)与非骨质疏松组(NOP组)进行对比分析,另测定正常健康51例绝经后女性(对照组)正位腰椎(L1~4)、左股骨颈BMD及血清IL-6水平作为对照。结果:与对照组比较,绝经后T2DM患者IL-6水平升高(t=2.636,P=0.009),左股骨颈及腰椎(L1~4)BMD均下降(t=-2.127,P=0.035;t=-2.026,P=0.045);OP组与NOP组比较IL-6升高(t=2.117,P=0.038),左股骨颈及腰椎(L1~4)BMD均下降(t=-7.274,P<0.001;t=-9.213,P<0.001)。结论:绝经后T2DM患者IL-6水平升高,绝经后T2DM患者腰椎、股骨颈BMD的降低与IL-6水平升高可能有一定的关系,IL-6水平升高对腰椎、股骨颈BMD的影响程度相似。
出处 《实用医学杂志》 CAS 北大核心 2009年第9期1425-1426,共2页 The Journal of Practical Medicine
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