摘要
目的探讨老年女性血尿酸（SUA）与代谢综合征（MS）及各代谢组分的相互关系。方法将147例年龄大于60岁的女性MS患者根据合并代谢组分的数量分为MSI、II、11I组，比较3组之间的SUA差异；采用四分位法将SUA分为4组，比较4组间代谢组分的差异。采用Logistic回归分析MS各代谢组分与SUA之间的相互关系。结果MSI、Ⅱ组与MS1N组的SUA水平比较，差异有统计学意义（P〈0．05）；SUA4个区间q25（〈44．31mg／L）、q50（44．31～53．24mg／L）、q75（〉53．24～62．68mg／L）和q100（〉62．68mg／L）患者的腰围、收缩压（SBP）、舒张压（DBP）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL—C）和空腹血糖（FPG）比较，差异均有统计学意义（P〈0．05）。与SUA〈44．31mg／L比较，SUA44．31～53．24、〉53．24～62．68、〉62．68mg／L3个区间的MS发生风险分别为1．87（95％CI1．35～2．59）、2．71（95％CI1．88～3．91）和4．88（95％Cj3．12～7．63）。suA的危险因素有腰围（OR=2．56，95％CI1．52～4．31）、TG（OR一2．21，95％CI1．63～3．00）、SBP（OR=1．68，95％cI1．33～2．12）、DBP（OR=1．84，95％CI1．41～2．40）、FPG（OR=2．16，95％CI1．68～2．78）和代谢组分合并数量（OR=2．87，95％CI1．89～4．36），SUA的保护因素有HDL—c（OR=0．48，95％C10．29～0．79）。结论sUA和MS各组分可能存在着相互作用。
Objective To discuss the relationship between serum uric acid（SUA） and the metabolic components in metabolic syndrome（MS）. Methods 147 female cases of MS aged 〉60 year old were divided into MS I group, MSⅡ group and MSⅢ group according to numbers of metabolic components, and the levels of SUA were compared among the three groups. These patients were also subdivided into 4 groups according to the SUA levels by the quartile division,and the differences of the metabolic compo- nents were compared among the 4 groups. The relationship between SUA and various metabolic components of MS was analyzed by Logistic regression analysis. Results The SUA level had statistical difference among the MS I group, MS II group and MS Ⅲ group（P〈0.05） ;the four SUA intervals of q25 （〈 44.31 mg/L）, q50 （44. 31 - 53. 24 mg/L）, q75 （ 〉 53. 24 - 62. 68 mg/L） and q100（〉62.68 μg/L） showed significant differences in waistline,SBP,DBP,TG, HDL-C and FPG（P〈0.05）. Compared with the SUA interval of 〈44.31 mg/L,the occurrence risk of MS in the SUA intervals of（44.31-53.24） ,〉（53. 24-62. 68） and 〉62.68 mg/L were 1.87（95%CI1.35-2.59） ,2.71（95%CI 1.88-3.91） and 4.88（95%CI 3.12-7.63） ,respectively. Waistline（OR= 2.56,95%CI 1.52-4.31）,TG（OR=2.21,95%CI 1.63-3.00）,SBP（OR=I. 68,95%CI 1.33-2.12）,DBP（OR=l. 84,95%CI 1.41-2.40） ,FPG（OR=2.16,95%CI 1.68-2.78） and numbers of metabolic components（OR= 2.87,95%CI 1.89-4.36） were the risk factors for SUA,and the HDL-C was the protective factor（OR=0.48,95%CI 0. 29-0. 79）. Conclusion There may be in- teraction between SUA and the metabolic components of MS.
出处
《重庆医学》
CAS
CSCD
北大核心
2014年第11期1329-1330,1334,共3页
Chongqing medicine
关键词
代谢综合征
尿酸
相关性分析
代谢组分
metabolic syndrome
uric acid
correlation analysis
relationship
