摘要
目的探讨中青年缺血性脑血管病患者血清基质金属蛋白酶-9(MMP-9)和溶血磷脂酸(LPA)与颈动脉粥样硬化(CAS)程度及斑块性质的关系。方法选择中青年缺血性脑血管病患者164例,根据颈动脉超声检查结果分为无斑块组、稳定斑组和易损斑组,并选择健康体检者60例作为对照组,所有对象检测血浆MMP-9、LPA水平,比较各组间血清值水平与斑块及硬化程度并进行相关性分析。结果斑块组血浆MMP-9、LPA水平较健康对照组浓度明显增高;易损斑块组血浆MMP-9、LPA水平增高显著(P<0.01),同时与稳定斑块组比较,亦有明显升高(P<0.01)。结论血浆MMP-9、LPA浓度可反映颈动脉内膜和斑块的稳定情况,可预测斑块破损,为临床检测及防治不稳定斑块提供理论依据,防止脑梗死的发生。
Objective To investigate the relationship between matrix metalloproteinaselaw-9 （MMP-9 ） ,lysophosphatidic acid（LPA）in blood plasma and degree of carotid artherosclerosis （CAS） and plaque’s character.Methods According to the carotid ultrasonic inspection’ s results ,164 young cases with cerebral arterial thrombosis were selected and divided into nonplaque group 、stable -plaque group 、instability plaque group ,60 healthy cases were chosen as control group.The level of MMP-9 and LPA of all cases were detected and compared and association analysis with plaque and sclerosis ’ degree was done.Results The plasma level of MMP-9 ,LPA in plaque group’s raised up obviously ,but that of the instability plaque group raised significantly （P〈 0.01） ,also significantly raisen compared with that of stable plaque group.Conclusion The plasma level of MMP-9 ,LPA can reflect stability of carotid’s intima and plaque ,also predict the damage of plaque and provide theory evidence for detection and prevention and cure instability plaque ,prevent the proceed of cerebral infarction.
出处
《中国实用神经疾病杂志》
2014年第6期20-21,共2页
Chinese Journal of Practical Nervous Diseases
