摘要
目的：探讨脂蛋白a[LP（a）]与N末端脑钠肽前体（NT-proBNP）在冠心病及冠状动脉狭窄程度中的作用。方法连续性收集我科行冠状动脉造影的患者121例，根据造影结果将患者分为冠心病组89例与对照组32例，对2组患者的临床及实验室资料，采用单因素和多因素Logistic回归分析LP（a）及NT-proBNP与冠心病及冠状动脉狭窄程度的关系。结果①单因素分析发现冠心病组中男性比例、LDL-C、LP（a）与NT-proBNP水平均高于对照组（P＜0．05），HDL-C水平低于对照组（P＜0．05），多因素Logistic回归分析仅NT-proBNP水平是冠心病的独立危险因素（OR：1．002，95％ CI：1．001～1．003；P＝0．003）。②冠状动脉中度狭窄组与轻度狭窄组比较：LP（a）、NT-proBNP水平均高于轻度狭窄组（P值分别为0．002，0．044），冠状动脉重度狭窄组与轻度狭窄组比较：LP（a）、NT-proBNP水平均高于轻度狭窄组（P值分别为0．001，＜0．001），随着冠状动脉狭窄程度加重，LP（a）、NT-proBNP水平呈增高趋势。结论 NT-proBNP是冠心病的独立危险因素，而LP（a）、NT-proBNP水平均与冠脉狭窄程度存在显著相关性。
Objective To investigate the effect of lipoprotein a[LP（a）]and N-terminal fragment of the prohormone brain-type na-triuretic peptide（NT-proBNP）on coronary heart disease and the degree of coronary artery stenosis.Methods A total of 121 patients under-went coronary angiography were continuously collected in our hospital,who were divided into coronary heart disease group with 89 patients and the control group with 32 patients,according to the results of coronary angiography.Clinical data and laboratory indexes were recorded in all patients.The single factor and multivariate logistic regression analysis were used to analyze the correlation between LP（a）and NT-proBNP and coronary heart disease and coronary artery stenosis degree.Results ①Univariate analysis revealed the proportion of male patients,and the level of LDL,LP（a）and NT-proBNP in coronary heart disease group were higher than those in control group（P〈0.05 ）.However,the HDL level was lower than control group（P〈0.05 ）.Multivariate logistic regression analysis showed that and the level of NT-proBNP（OR 1.002,95%CI：1.001-1.003;P=0.003）was an independent risk factor for coronary heart disease.②Comparison of coronary artery stenosis in patients with moderate and mild stenosis：the LP（a）level and NT-proBNP level were higher than those in mild stenosis （P=0.002, 0.044）.Compared to mild coronary artery stenosis,the LP（a）level and NT-proBNP level were higher in severe stenosis （P=0.001,〈0.001）.With the degree of coronary artery stenosis aggravating,the level of LP（a）and NT-proBNP also increased.Conclusion The level of NT-proBNP is an independent risk factor for coronary heart disease.The LP（a）level and NT-proBNP level are significantly associated with the degree of coronary artery stenosis.
出处
《安徽医学》
2014年第3期304-307,共4页
Anhui Medical Journal
关键词
冠心病
N末端脑钠肽前体
冠状动脉造影
脂蛋白a
Coronary heart disease
Lipoprotein a
N-terminal fragment of the prohormone brain-type natriuretic peptide
Coronary arteriography
