摘要
创面修复是一个既古老又现代的医学问题。说它古老，因为创面修复行为是机体的本能，甚至早于人类，大猩猩用舌头舔伤口就是一个佐证；说它现代，是因为人类对创面愈合的认识自20世纪80年代末到90年代初才从组织学和细胞功能学水平上升至对生长因子的认识，才逐渐认识到创面愈合过程是由一个复杂的网络在调控。
The understanding of the mechanism of wound healing is deepening. Key issues in the process of wound healing need to be seriously considered, i.e. how to establish the concept of application of phasic and selective means to pro- mote wound healing according to the characteristics of a network and sequential process; to correctly assess the function and sta- tus of macrophages in wound healing and to explore the condi- tions of regulating timelv infiltration of macrophages, as well as the phasic and orderly expression of type I and type II macro- phages; to properly understand the rode and status of extracellu- lar matrix components or the three-dimensional structure and morphology in wound healing; to elucidate the effects of wound microenvironment on the proliferation and differentiation of stem cells; to find out the intrinsic mechanism of negative pressure in the process of wound healing. The understanding of the above problems are of great value for us to grasp the intrinsic mecha- nism of wound healing in order to establish a more effective and rational treatment of wound.
出处
《中华烧伤杂志》
CAS
CSCD
北大核心
2014年第2期95-99,共5页
Chinese Journal of Burns
