摘要
目的:观察解毒醒脑液灌肠治疗肝硬变早期肝性脑病的临床疗效及对血氨、内毒素、肿瘤坏死因子-α的影响。方法:63例肝硬变早期肝性脑病患者随机分为治疗组32例和对照组31例。治疗组应用中药解毒醒脑液灌肠配合基础治疗,对照组应用乳果糖保留灌肠配合基础治疗,比较两组患者的临床疗效。结果:治疗组有效率93.33%,对照组有效率90.00%,两组有效率比较,差异无统计学意义(P>0.05)。治疗组首次意识、智力(认知力、定向力、记忆力、计算力)、扑翼样震颤改善时间较对照组缩短,但两组比较,差异无统计学意义(P>0.05)。治疗1周后治疗组患者血氨、内毒素、肿瘤坏死因子-α、谷丙转氨酶及总胆红素浓度较对照组显著下降(P<0.05)。结论:中药解毒醒脑液灌肠配合基础治疗可以较快改善肝性脑病患者认知力、定向力、记忆力、计算力、行为异常、扑翼样震颤等体征。在降低血清血氨、内毒素、肿瘤坏死因子-α、谷丙转氨酶及总胆红素水平等方面优于乳果糖。
Objective ： To evaluate the clinical curative effect of early cirrhosis hepatic encephalopathy with Jieduxingnao Fluid enema, and the effect of Jieduxingnao Fluid on the blood ammonia, lipopolysaccharide and tumor necrosis factor-et. Methods ： 63 cases with cir- rhotic early hepatic eneephalopathy were randomly divided into the treatment group of 32 cases and the control group of 31 cases. The treatment group was given Chinese medicine Jieduxingnao Fluid combined with basic treatment, and the control group was given laetu- lose retention enema combined with basic treatment. Compared the clinical efficacy of two groups of patients. Results：The effective rate of the two groups was 93.33% and 90.00% respectively ,and there was no statistically significant difference. Consciousness for the first time, intelligence （cognition ,orientation, memory and computing power） ,asterixis improvement time of the treatment group were short- ened compared with that of the control group, and there was no difference between the two groups （ P 〉 O. 05 ） ; One week after treat- ment,levels of blood ammonia, lipopolysaccharide, tumor necrosis factor-a, alanine amino transferase and total bilirubin of the treatment group were significantly lower that of the control group （ P 〈 0.05 ）. Conclusion ： Chinese medicine Jieduxingnao Fluid combined with basic treatment can rapidly improve consciousness, cognition, directional force, memory, computing power, abnormal behavior and as- terixis in patients with hepatic encephalopathy and significantly reduce serum level of blood ammonia, lipopolysaecharide, tumor necrosis factor-a, alanine amino transferase and total bilirubin, and the clinical curative effect is better than that of lactulose.
出处
《中医学报》
CAS
2014年第4期577-579,共3页
Acta Chinese Medicine
基金
河南省教育厅科技攻关项目(编号:2010A360026)
关键词
肝性脑病
肝硬变
解毒醒脑液
血氨
内毒素
肿瘤坏死因子-Α
hepatic encephalopathy
cirrhosis
jieduxingnao fluid
blood ammonia
lipopolysaccharide
tumor necrosis factor-or
