摘要
目的探究血清可溶性CD146(sCD146)、可溶性致癌抑制因子2(sST2)水平与心肺复苏成功患者预后的相关性。方法选取2019年1月至2022年8月期间本院急诊科收诊的116例心脏骤停且心肺复苏成功的患者并设为心肺复苏成功组,另选取同期健康体检志愿者118例为对照组。采用酶联免疫吸附试验(ELISA)对比两组血清sCD146、sST2水平,根据心肺复苏成功患者短期预后将其分为预后良好组(n=95)和预后不良组(n=21),Cox多因素分析心肺复苏成功患者预后的影响因素,受试者工作特征(ROC)曲线分析血清sCD146、sST2水平对心脏复苏成功预后的预测价值。结果与对照组比较,心肺复苏成功组血清sCD146、sST2水平均明显升高(P<0.05);预后不良组血清sCD146、sST2水平明显高于预后良好组(P<0.05);预后不良组和预后良好组心肺复苏开始时间、心肺复苏持续时间、肾上腺素用量和合并心脏疾病比较差异具有统计学意义(P<0.05);Cox多因素分析结果显示,血清sCD146、sST2、心肺复苏开始时间、心肺复苏持续时间和合并心肺疾病均是影响心肺复苏成功患者预后的因素(P<0.05)。ROC结果显示,血清sCD146和sST2水平单独预测心肺复苏成功患者预后的AUC分别为0.732和0.758,最佳截断值分别为221.00ng/mL和61.50μg/L,灵敏度分别为71.43%和66.67%,特异性分别为85.26%和88.42%;两者联合预测心肺复苏成功患者预后的AUC为0.876,显著大于血清sCD146水平单独预测的AUC(Z=1.969,P=0.049)和sST2水平单独预测的AUC(Z=2.160,P=0.031)。结论血清sCD146和sST2水平有望成为预测心肺复苏成功患者预后的指标。
Objective To investigate the correlation between serum levels of soluble CD146(sCD146)and soluble suppression of tumorigenicity 2(sST2)and the prognosis of patients with successful cardiopulmonary resuscitation.Methods A total of 116 patients with cardiac arrest and successful cardiopulmonary resuscitation admitted to the Emergency Department of our hospital from January,2019 to August,2022 were collected and assigned to the successful cardiopulmonary resuscitation group,while 118 healthy volunteers were collected as the control group.Enzyme linked immunosorbent assay(ELISA)was applied to compare levels of serum sCD146 and sST2 between these two groups.According to the short-term prognosis of successful cardiopulmonary resuscitation patients,these patients were grouped into a good prognosis group(n=95)and a poor prognosis group(n=21).Cox multivariate analysis was applied to identify the influencing factors of prognosis in patients with successful cardiopulmonary resuscitation.Receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of serum sCD146 and sST2 levels for the successful prognosis of cardiac resuscitation.Results Compared with the control group,serum levels of sCD146 and sST2 in the successful CPR groups were significantly increased(P<0.05);Serum levels of sCD146 and sST2 in the poor prognosis group were significantly higher than those in the good prognosis group(P<0.05);There was a significant difference between the poor prognosis group and the good prognosis group in terms of the start time,duration of cardiopulmonary resuscitation,adrenaline dosage,and comorbid heart disease(P<0.05);Cox multivariate analysis showed that serum sCD146,sST2,start time of cardiopulmonary resuscitation,duration of cardiopulmonary resuscitation,and concomitant cardiopulmonary disease were all factors that affected the prognosis of successful cardiopulmonary resuscitation patients(P<0.05).ROC results showed that AUCs of serum sCD146 and sST2 levels alone in predicting the prognosis of successfu
作者
常乃奇
张勇
CHANG Naiqi;ZHANG Yong(Department of Geriatrics,Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010000,China)
出处
《标记免疫分析与临床》
CAS
2023年第12期2065-2070,共6页
Labeled Immunoassays and Clinical Medicine
关键词
可溶性CD146
可溶性致癌抑制因子2
心肺复苏
预后
Soluble CD146
Soluble suppression of tumorigenicity 2
Cardiopulmonary resuscitation
Prognosis
