摘要
目的探讨2型糖尿病患者24h尿钠与脂代谢的关系。方法收集2012年9月至2013年7月第三军医大学大坪医院200例2型糖尿病住院患者一般资料，测定血脂、空腹血糖、24h尿钠等生化指标。采用单因素方差分析、Logistic回归分析等方法分析尿钠排泄与脂代谢的关系。结果按24h尿钠四分位数分为低尿钠组、中尿钠组、中高尿钠组、高尿钠组，四组三酰甘油呈逐渐增高趋势，高尿钠组三酰甘油[1．87mmol／L（1．24～3．93mm01／L）]显著高于低尿钠组[1．43mmol／L（1．13—2．20mmol／L），P=0．015]，Logistic回归分析提示尿钠排泄增多是高三酰甘油血症的独立危险因素[OR（95％CI）：1．006（1．001，1．010），P=0．010]。结论高盐膳食是2型糖尿病患者高三酰甘油血症的重要危险因素，控制钠盐摄入可能有助于改善糖尿病患者血脂紊乱。
Objective To explore the relationship between 24-h urinary sodium and lipid metabolism in patients with type 2 diabetes. Methods Two hundred in-patients with type 2 diabetes were enrolled and 24-h urinary sodium, fasting blood glu- cose and lipid parameters were measured. One-way ANOVA and Logistic regression analysis were performed to investigate the impacts of 24-h urinary sodium on dyslipidemia. Results The subjects were divided into 4 groups according to quartiles of the 24-h urinary sodium. There was an increasing trend in triglycerides among the four groups. The concentration of plas- ma triglyceride was significantly higher in patients with the highest quartile of the 24-h urinary sodium than that with the lowest urinary sodium （ 1.87 [ 1.24 - 3.93] mmol/L vs 1.43[1. 13 - 2. 20 ] mmol/L,P = 0. 015 ）. Logistic regression analy- sis showed that 24-h urinary sodium was the independent risk of hyperlipidemia in type 2 diabetes （ OR[ 95% CI] ： 1. 006 [ 1. 001,1. 010] ,P = 0. 010）. Conclusion High salt intake may be an important risk factor in hypertriglyceridemia and control of sodium intake will prevent dyslipidemia in patients with type 2 diabetes.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2014年第4期360-363,共4页
Chinese Journal of Practical Internal Medicine
基金
国家重点基础研究发展计划(2012CB517805)
第三军医大学临床医学重大科研项目(2012XLC08)
重庆市科技攻关项目(CSTC2019gg-yyjs10062)
关键词
尿钠
血脂
2型糖尿病
urinary sodium
triglyceride
type 2 diabetes
