摘要
目的探讨LASIK治疗近视散光眼术后高阶像差变化与切削量、治疗光区直径和术后角膜后表面前凸值的相关性。方法随机选取采用飞秒激光制瓣波前像差引导LASIK治疗的近视散光患者69例(138眼),采集患者术前和术后6个月的高阶像差值、角膜后表面前凸值,记录患者的治疗光区直径和切削量,采用多元逐级回归分析探讨手术切削量、治疗光区直径和术后角膜后表面前凸值与术后高阶像差的相关性。结果术中手术切削量为(96.26±25.14)μm,治疗光区直径为(6324.00±297.00)μm,术后6个月角膜后表面前凸值为(47.62±15.00)μm;术后6个月瞳孔直径6 mm区的总体高阶像差和去球差高阶像差均方根值分别为(0.78±0.26)μm、(0.56±0.23)μm,术前为(0.49±0.21)μm、(0.45±0.22)μm,差异均有统计学意义(均为P<0.01)。术后6个月瞳孔直径6 mm区的总体高阶像差和去球差高阶像差均方根值与手术切削量(r=0.62、0.46,均为P<0.01)、术后角膜后表面前凸值(r=0.49、0.45,均为P<0.01)均呈正线性相关,与治疗光区直径(r=-0.56、-0.47,均为P<0.01)均呈负线性相关。结论 LASIK治疗近视散光眼术后高阶像差较术前增大,术后高阶像差增加与手术切削量、术后角膜后表面前凸值呈正线性相关,与治疗光区直径呈负线性相关。
Objective To analyze the correlation of higher order aberration changes with ablation depth, optic zone diameter and posterior corneal surface protru- sion after LASIK for myopia and astigmatism. Methods This prospective study com- prised 138 eyes of 69 patients treated with wavefront-guided LASIK who were available for evaluation at 6 months. The total high order aberrations, posterior corneal surface protrusion, ablation depth and optic zone diameter were measured before and after 6 months postoperatively. Multiple regression analysis was used to assess the factors that affect the change of the higher order aberrations after LASIK. Results The intra-oper- ative ablation depth was （ 96.26 ± 25. 14 ） μm, the optic zone diameter was （ 6324.00 ±297.00）μm, the posterior corneal surface protrusion at postoperative 6 months was （47.62 ±15.00 ） μm. At postoperative 6 months, the total higher order aberrations root mean square （HOARMS）and without spherical aberration HOARMS at 6 mm pupil size were （0.78 ± 0.26 ） μm, （0.56± 0.23 ）μm, which were higher than pre-operation （0.49 ± 0.21 ）μm and（ 0.45 ± 0.22 ）μm, there were significant differences （all P 〈 0.01 ）. Both ablation depth（ r = 0.62,0.46, all P 〈 0.01 ） and posterior corneal surface protrusion（ r =0.49,0.45, all P 〈 0.01 ） showed positive linearity correlations with the total HOARMS and despherical aberration HOARMS. There was a negative linearity correlation between optic zone diameter and total HOARMS, without spherical aberration HOARMS （ r = - 0.55, - 0.47, all P 〈 0.01 ）. Conclusion The postoperative higher order aberration is higher than pre-op- eration after LASIK for myopia and astigmatism, which are positive linearity correlated with ablation depth, posterior corneal surface protrusion, and negative linearity correlated with optic zone diameter.
出处
《眼科新进展》
CAS
北大核心
2014年第4期352-354,共3页
Recent Advances in Ophthalmology
