摘要
目的:探讨健脾生血颗粒治疗小儿缺铁性贫血的疗效与安全性及其对相关指标的影响。方法:选取2011年1月至2012年12月来我院门诊治疗的小儿缺铁性贫血患儿92例,采用随机数表法分为观察组和对照组各46例。观察组给予健脾生血颗粒治疗,≤1岁每次2.5 g,>1岁~3岁每次5 g,>3岁~5岁每次7.5 g,每日3次饭后温开水冲服;对照组给予右旋糖酐铁口服液治疗,体质量≤5 kg 5 mL/d,>5 kg^9 kg 10 mL/d,>9 kg 10~20 mL/d,每天分3次口服。1个月为1疗程,共治疗2个疗程。观察疗效、相关指标变化及不良反应情况,治疗后6个月随访复发情况。结果:治疗2个月,两组均取得较好疗效,痊愈率及总有效率比较差异均无统计学意义(P>0.05);RBC、Hb、Hct、MCV、MCH、MCHC均明显升高(P<0.01),且两组间比较差异无统计学意义(P>0.05);SF、SI、TIBC均明显改善(P<0.01),但观察组SF、SI水平高于对照组(P<0.05),TIBC水平低于对照组(P<0.01)。两组不良反应发生率差异无统计学意义(P>0.05),但观察组复发率(8.7%)低于对照组(23.9%)(P<0.05)。结论:健脾生血颗粒治疗小儿缺铁性贫血疗效满意,能明显改善红细胞、血清铁水平,体现了中西医结合治疗"标本兼治"的优势,且不良反应少,复发率低,值得临床推广应用。
Objective：To investigate the clinical efficacy, safety, influence of the related indexes and relapse conditions. Methods： Ninety-two children with iron deficiency anemia were selected as the research objects. They were randomly divided into an observation group and a control group （each group =46 cases）. The observation group was treated with Jianpi Shengxue granule, children under 1 year old 2.5 g everytime, 〉 1 N 3 years old 5 g cverytime, 〉3 N 5 years old 7.5 g everytimc,3 times a day mixed with warm boiled water after meal; the control group was treated with iron dextran oral liquid, children ≤ 5 kg 5 mL/d, 〉5 -9 kg 10 mL/d, 〉9 kg 10 - 20 mL/d, divided into 3 times a day orally. One month was a course within 2 courses. After treatment for two months, the clinical curative effects were comparatively analyzed ; the changes of related indicators and adverse reactions were observed. After six months＇ follow-up, relapse of the two groups was observed. Results： After treatment for two months, the two groups all achieved good clinical effect; the cure rate and total effective rate of the observation group were slightly higher than those of the control group, but there were no statistically significant differences （P〉0.05）. The RBC, Hb, Hct, MCV, MCH, MCHC indexes of the two groups after treatment were significantly increased than those before treatment; the difference had statistically significant （P〈0.01）, but there was no statistically significant difference between the two groups （P〉0.05）. The SF, SI, TIBC indexes of the two groups after treatment were obviously improved than those before treatment, and the differences were statistically significant （P〈0.01） , but SF, SI levels of the observation group after treatment were obviously higher than those of the control group （ P〈0.05 ） ; TIBC level was significantly lower than that of the control group （P〈0.01）. The incidence of adverse reactions in the observation group was lower than that in the control grou
出处
《儿科药学杂志》
CAS
2014年第4期36-38,共3页
Journal of Pediatric Pharmacy
