摘要
目的探讨乳腺癌患者术后化疗后感染状况,并进行临床分析,为临床预防医院感染提供参考依据。方法以2009年1月-2013年1月医院收治的96例乳腺癌手术化疗后发生感染患者为研究对象,留取咽拭子、口腔溃烂组织、尿液、粪便、皮肤渗出液、血液等标本,采用常规的细菌鉴定及药敏试验,对其进行临床分析,找出引发术后化疗后感染的发病部位、病原菌及危险因素。结果 96例乳腺癌术后化疗感染患者中院内感染占42.71%,院外感染占57.29%;感染共121例次,感染类型以呼吸道感染为主,47例次占38.84%,其次为消化道感染36例次占29.75%;96例乳腺癌手术化疗后感染患者中检出病原菌以革兰阴性菌为主占45.45%,分别为铜绿假单胞菌、肺炎克雷伯菌、大肠埃希菌,分别占17.36%、15.70、12.40%。结论乳腺癌患者手术化疗后机体免疫力急剧下降,是医院感染的高危人群,医护人员应积极采取针对性措施,以避免或降低乳腺癌患者术后感染的发生。
OBJECTIVE To discuss and analyze the situation of infection after operative chemotherapy in patients with breast cancer, so as to provide reference to prevent hospital infections in clinic. METHODS 96 breast cancer patients who treated in our hospital from Jan. 2009 to Jan. 2013 and got infection after operative chemotherapy were selected as the objects of study. The specimens of throat swabs, oral ulcer tissues, urine, stool, skin exudates, blood and so on of these patients were gotten, and analyzed clinically by conventional identification of bacteria and drug sensitivity test, then the pathogenic sites, pathogenic bacteria and risk factors which caused postoperative postchemotherapy infection were found out. RESULTS Among the 96 breast cancer patients with infection after operative chemotherapy, 42.71% of patients got infections in hospital, 57.29% got infections out- side of the hospital. Total infection cases-time was 121. The main type of infection was respiratory tract infec- tions, 47 cases and 38.84 % of the total infection rate, the second was alimentary infection, 36 cases and 29.75 of the total infection rate, the third was skin and soft tissue infection, 31 cases and 25.62% of the total infection rate. The main pathogenic bacteria of infection after operative chemotherapy in 96 patients with breast cancer were gram negative bacilli, accounting for 45.46 %, which were Pseudomonas aeruginosa, Klebsiella pneumoniae and Escherichia coli, accounting for 17. 36%, 15. 70 and 12. 40%. CONCLUSION Breast cancer patients, whose immunity drop sharply after surgery and chemotherapy, are the high risk population of nosocomial infection. Med- ical workers should actively take specific measures to avoid or reduce the occurrence of postoperative infection in patients with breast cancer.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2014年第8期2016-2018,共3页
Chinese Journal of Nosocomiology
基金
湖北省卫生厅科研基金资助项目(JX3B52)
关键词
乳腺癌
化疗
临床分析
病原菌
Breast cancer
Chemotherapy
Clinical analysis
Pathogenic bacterium
