摘要
目的探讨CD64指数、C反应蛋白(CRP)与清蛋白(Alb)比值(CRP/Alb)对乳腺癌改良根治术后感染的预测价值。方法回顾性分析2018年1月至2021年8月安徽省第二人民医院203例行乳腺癌改良根治术患者的临床资料,根据患者术后1个月是否发生感染分为感染组(40例)与未感染组(163例)。术后第1天采用流式细胞仪检测血清CD64指数,免疫比浊法检测血清CRP、Alb水平,同时计算CRP/Alb。采用受试者工作特征(ROC)曲线评估两组中CD64指数、CRP/Alb对乳腺癌改良根治术后感染的诊断价值,采用多因素logistic回归分析探讨乳腺癌改良根治术后感染的影响因素。结果感染组患者CD64指数、CRP水平、CRP/Alb均高于未感染组[5.7±1.1比1.5±0.3,t=32.05,P<0.001;(78±13)mg/L比(11±3)mg/L,t=39.26,P<0.001;3.09±0.42比0.36±0.02,t=57.48,P<0.001],感染组Alb水平低于未感染组[(25±3)g/L比(32±4)g/L,t=8.37,P<0.001]。乳腺癌改良根治术术后感染组和未感染组患者置管时间、CD64指数、CRP/Alb差异均有统计学意义(均P<0.05);多因素logistic回归分析显示,置管时间>9 d、CD64指数>42.65、CRP/Alb>1.25均为影响乳腺癌改良根治术后感染的危险因素(均P<0.001)。ROC曲线结果显示,CD64指数诊断乳腺癌改良根治术后感染的曲线下面积、灵敏度、特异度分别为0.804、89.5%、85.4%,CRP分别为0.712、70.6%、76.5%,Alb分别为0.766、72.4%、75.4%,CRP/Alb分别为0.856、88.0%、90.5%。结论CD64指数、CRP/Alb对乳腺癌改良根治术后感染具有一定的预测价值。
Objective To investigate the value of CD64 index and C-reactive protein(CRP)/albumin(Alb)ratio(CRP/Alb)in predicting infection after modified radical mastectomy for breast cancer.Methods The clinical data of 203 breast cancer patients who underwent modified radical mastectomy from January 2018 to August 2021 in Anhui No.2 Provincial People's Hospital were retrospectively analyzed.All cases were divided into infection group(40 cases)and non-infection group(163 cases)according to whether they were infected at the 1st month after operation.On the 1st day after operation,the serum CD64 index was measured by using flow cytometry,the serum CRP and Alb levels were measured by using immunoturbidimetry,and the CRP/Alb was calculated.The values of CD64 index and CRP/Alb in the diagnosis of infection after modified radical mastectomy for breast cancer were evaluated by using receiver operating characteristic(ROC)curve.The factors influencing infection after modified radical mastectomy for breast cancer were explored by using multivariate logistic regression.Results The levels of CD64 index,CRP,CRP/Alb in the infection group were higher than those in the non-infection group[5.7±1.1 vs.1.5±0.3,t=32.05,P<0.001;(78±13)mg/L vs.(11±3)mg/L,t=39.26,P<0.001;3.09±0.42 vs.0.36±0.02,t=57.48,P<0.001],and the level of Alb in the infection group was lower than that in the non-infection group[(25±3)g/L vs.(32±4)g/L,t=8.37,P<0.001].There were statistically significant differences in the catheterization time,CD64 index and CRP/Alb between the infection group and non-infection group(all P<0.05);multivariate logistic regression showed that catheterization time>9 d,CD64 index>42.65 and CRP/Alb>1.25 were risk influencing factors of infection after modified radical mastectomy for breast cancer(all P<0.001).The ROC curve results showed that the area under the curve,sensitivity,and specificity of CD64 index in the diagnosis of infection after modified radical mastectomy for breast cancer were 0.804,89.5%and 85.4%,the CRP were 0.712,70.6%and
作者
祝保玺
王锐
任小伟
黄建康
Zhu Baoxi;Wang Rui;Ren Xiaowei;Huang Jiankang(Department of Thyroid and Breast Surgery,Anhui No.2 Provincial People's Hospital,Hefei 230000,China)
出处
《肿瘤研究与临床》
CAS
2023年第2期124-127,共4页
Cancer Research and Clinic
