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SH2衔接蛋白1基因在体内能量代谢调节中的作用 被引量：3

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摘要 肥胖是指体内脂肪细胞的体积和数目增加,体脂占体重的百分比异常增高或在某些局部（如腹部）过多沉积,对健康造成一定影响的慢性代谢性疾病.肥胖的发病机制十分复杂,环境因素与遗传易感性相互作用占主导地位.近来的全基因组关联性研究（GWAS）发现了一批与肥胖症及能量代谢相关的新基因,如跨膜蛋白18、葡糖胺-6-磷酸脱氨酶、含钾通道四聚化结构域15及SH2衔接蛋白1（SH2B1）等,但大部分的具体功能仍不清楚.本文着重介绍SH2B1在能量代谢中的作用,及其基因多态性与肥胖、胰岛素抵抗等代谢性指标的相关性.
作者 李世蕊 邢小燕
机构地区 中日友好医院内分泌科
出处 《中华糖尿病杂志》 CAS CSCD 2014年第3期187-190,共4页 CHINESE JOURNAL OF DIABETES MELLITUS
关键词 蛋白1基因 能量代谢 代谢调节 体内 慢性代谢性疾病 遗传易感性 基因多态性 代谢性指标
分类号 R589.2 [医药卫生—内分泌]
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参考文献34

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二级参考文献20

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中华糖尿病杂志
2014年 第3期

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