摘要
CD44是一种重要的跨膜糖蛋白,它是透明质酸主要的细胞表面受体,通过参与细胞黏附、迁移以及生长,调控肿瘤的发展。CD44及其变异型与胃癌的发生、分化、淋巴结转移以及不同病理类型的预后密切相关。幽门螺杆菌可通过直接作用和局部炎性反应增加CD44和CD44v9表达。CD44阳性的胃癌细胞具备肿瘤干细胞特性,针对CD44的研究可能会为胃癌的诊断和治疗提供理想方法。
CD44, an important transmembrane glycoprotein, is a principal cell surface receptor for hyalu- ronic acid. It is well recognized that CD44 may participate in cancer progression such as adhesion, migration and growth regulation. Studies suggest that CD44 and its splice variants might have close relations with carci- nogenesis, differentiation,lymph node metastasis and prognosis of gastric cancer. Either directly or through a local inflammatory response, H. pylori is responsible for increased expression of CD44 and CD44r9. CD44＋ gas- tile cancer cells show the cancer stem cell properties. Further studies focusing on CD44 may provide ideal approaches for diagnosis and therapy of gastric cancer.
出处
《医学综述》
2014年第6期1029-1033,共5页
Medical Recapitulate
