摘要
目的探讨CD44V9在大肠癌组织中的表达,分析其与临床病理因素及其预后的关系。方法采用免疫组化S-P法,检测了24例大肠癌患者癌组织和癌旁组织中的表达水平。结果大肠癌组CD44V9阳性表达率为高于癌旁组织(P=0.000);伴有远处淋巴转移的大肠癌组高于无淋巴转移组(P=0.001);高中分化的大肠癌组与低分化、黏液腺癌组的CD44V9阳性表达无显著性差别(P=0.282)。结论 CD44V9在大肠癌发生、发展、侵袭转移过程中起重要作用,检测其表达水平有助于对预后的判断。
Objective To discuss the expression of CD44V9 in the patient＇s tissues with colorectal carcinoma,and to analyse the re- lationship between the expression of CD44V9 with the clinical pathology and prognosis. Methods The expression of CD44V9 in cancer tissues and peficancerous tissues of 24 patients were observed by immunohistochemical technique. Results The expression of CD44V9 in cancer tissues was much high than in the peficancerous tissues（P = 0. 000）. The expression of CD44V9 in patients with lymph node me- tastasis was much high than without lymph node metastasis（ P = 0. 001 ）. There was no significant difference between the high - moderately differentiated cancers and the poorly differentiated cancers（P = 0. 028）. Conclusion The expression of CD44V9 is correlated with the progress,infiltration and metastasis of the colorectal carcinoma,and may be helpful to jugde the prognosis.
出处
《医学研究杂志》
2012年第7期98-100,共3页
Journal of Medical Research
基金
温州市科技计划基金资助项目(Y20100128)
