摘要
目的研究结肠癌患者手术前后血清肝细胞生长因子(hepatocyte growth factor,HGF)动态变化的规律,并探讨其临床意义。方法采用酶联免疫吸附测定法测定加例结肠癌患者术前,术后第1、3、7天血清中HGF的含量,20例健康查体人群作对照,同一患者同时做手术前后自身对照。结果结肠癌伴淋巴结转移者术前血清HGF明显升高,升高的阳性率达52.5%,HGF诊断结肠癌的敏感度为52.5%,特异度为95.0%;所有HGF检测阳性者术后HGF逐渐降低,于术后第7天HGF降低到术前水平的50.0%以上,尤其是伴淋巴结转移者,HGF下降更明显(P<0.05)。结论结肠癌患者可有HGF不同程度升高,尤其以伴淋巴结转移者术前血清HGF升高更明显,术后HGF逐渐下降,对评估手术疗效有一定意义。
Objective To evaluate the change and clinical significance of serum hepatocyte growth factor（HGF） in colon cancer patients before and after surgery.Methods The levels of HGF were detected in 40 colon cancer patients before surgery,and after operation 1,3,7 days,and 20 healthy persons served as control group.Results The serum HGF in colon cancer patients with lymph node metastasis was significantly higher before surgery,the positive rate was up to 52.5%.HGF diagnostic sensitivity of colon cancer was 52.5%,specificity of 95.0%.HGF in all patients who were tested positive HGF decreased gradually after surgery,and in the seventh day after surgery,HGF decreased to pre-operative level above 50.0%,especially in lymph node metastasis,HGF decreased more significantly（P＜0.05）.Conclusion HGF in colon cancer patients may have increased to varying degrees,particularly in the lymph node metastasis,pre-operative serum HGF increased more significantly,but after surgery,HGF decreased gradually,the study has certain value in the assessment of the surgery effect.
出处
《河北医科大学学报》
CAS
2014年第3期266-268,共3页
Journal of Hebei Medical University
关键词
结肠肿瘤
肝细胞生长因子
血清
clonic neoplasms
hepatocyte growth factor
serum
