摘要
目的:探讨血清中肝细胞生长因子(HGF)测定在大肠癌肝转移患者诊断中的价值。方法:采用酶联免疫测定(EIA)法测定52例均经病理确诊的大肠癌患者血清中HGF含量,其中合并肝转移17例,并以20例健康者为对照。结果:52例大肠癌患者与对照组相比较,血清中HGF含量显著升高(P<0.05),且分期越晚,HGF值越高,而其中17例合并肝转移的大肠癌患者较之无转移的大肠癌患者,HGF值更高(P<0.05)。结论:HGF可以作为大肠癌的一个血清学指标,对大肠癌的诊断、分期和预后的判断可能具有一定的价值,特别是对于大肠癌患者有无肝转移将是一个较好的判断指标。
Objective ： To explore the clinical value of measurement of the serum content of hepatocyte growth factor （HGF） in colon cancer patients. Methods：Serum samples of colon cancer patients （n = 52） were examined for HGF content measurement by the quantitative EIA. Among them,17 patients had diagnosed liver metastasis before test. Also serum HGF contents were measured in the antitheses groups, whom come from department of check-up of our hospital. Results：The level of total HGF in malignant tumor group was significantly higher than those in antitheses groups （P 〈 0.05 ） , and the number of HGF higher combined with stages. There was no significant differences of serum HGF contents was seen between the Duck＇s A,Duck＇s B and Duck＇s C. But Duck＇s C＇s level of contents of serum HGF was higher than Duck＇s B＇s. There was significant difference between patients with or not liver metastasis （ P 〈 0. 05 ）. Conclusion：HGF may be anew useful a serum marker of colon cancer and may be have a value for diagnoses ,stages and estimation prognosis for colon cancer patients. Especially it is being a good study target for colon cancer patients whether or not liver metastasis.
出处
《临床肿瘤学杂志》
CAS
2007年第11期822-824,共3页
Chinese Clinical Oncology
基金
广东省医学科学技术研究基金课题(A2004802)
