摘要
目的观察整肠生、常乐康联合应用治疗伴有肠道菌群失调功能性腹泻的临床疗效及其对肠道定植抗力的影响。方法选取符合入组条件的门诊患者共64例,随机分为整肠生(A)组22例、整肠生+常乐康(B)组21例、常乐康(C)组21例。1个月后观察各组临床疗效。结果改善消化道症状有效率整肠生组为55%,联合用药组为90%,常乐康组为55%;改善肠道整体菌群有效率分别为25%、70%、30%;改善B/E值有效率分别为65%、90%、60%。联合用药组与单独使用整肠生或常乐康组差异均有统计学意义(P<0.05)。试验中三个治疗组均无明显不良反应事件发生。结论单独应用整肠生或常乐康、以及两药联合应用均能有效的改善功能性腹泻的症状、调整肠道菌群、增强肠道定植抗力,其中联合用药组的疗效更显著。
Objective To observe the clinical efficacy of Zheng ChangSheng combined with Chang LeKang on pa- tients with functional diarrhea accompanied by aheration of intestinal flora and its effects on colonization resistance. Methods A total of 64 eligible outpatients were recruited and randomized into three groups： Zheng ChangSheng group （22 cases） , Zheng ChangSheng combined Chang LeKang group （21 cases） , and Chang LeKang group （21 cases）. The clinical efficacy of each group was detected after 1-month treatment. Results The digestive symptoms of all groups were improved, with the efficacy rate of Zheng Chang Sbeng group being 55% , the combination group 90% and Chang Le Kang group 55% , respectively; The efficacy rates of whole intestinal flora improvement were 25% , 70% and 30% , respectively; The efficacy rates of B/E ratio improvement were 65% , 90% and 60% , re- spectively. Noticeable statistical differences were observed between the combination group and either of the other groups （P 〈 0.05 ）. No obvious adverse effects were found in three groups. Conclusion Zheng ChangSheng or Chang LeKang alone or in combination can regulate the intestinal flora, improve the digestive symptoms and strengthen the colonization resistance of the flora. Combination of the two drugs is more effective .
出处
《中国微生态学杂志》
CAS
CSCD
2014年第3期284-289,共6页
Chinese Journal of Microecology
关键词
整肠生
常乐康
肠道菌群失调
功能性腹泻
肠道定植抗力
Zheng ChangSheng
Chang LeKang
Alteration of intestinal flora
Functional diarrhea
Colonization resistance
