摘要
目的：评价血清半乳糖凝集素-3（galectin-3）水平与慢性心力衰竭（chronic heart failure，CHF）患者预后之间的关系。方法检索Pubmed、Embase、Cochrane图书馆、中国生物医学文献数据库、中国知网、万方等数据库，筛选关于半乳糖凝集素-3与CHF预后关系的中英文文献，提取风险比（hazard ratio， HR）及其95%可信区间（confidence interval，CI）。对纳入的文献进行质量评价，采用STATA 12.0软件进行Meta分析。结果纳入6篇符合要求的文献，异质性检验表明研究具有异质性，随机效应模型合并统计量显示在未排除其他影响因素的情况下，半乳糖凝集素-3预测CHF的HR＝1.63，95%CI 1.26～2.11；排除其他影响因素后，HR＝1.23，95%CI 1.07～1.42。结论高水平半乳糖凝集素-3可能是CHF不良预后的独立危险因素。
Objective To evaluate the relation between serum galectin-3 level and chronic heart failure （CHF） prognosis. Methods Articles which involved relation between galectin-3 and CHF prognosis were searched in Pubmed, Embase, Cochrane Library, Chinese Biomedical Literature Database, CNKI and WANFANG Databases. Hazard ratio （HR） and 95%confidence interval （CI） in each literature were extracted for meta-analysis using STATA 12.0 software. Results Six literature complying with the requirements were included. Heterogeneity test showed that heterogeneity exists in different studies, and statistics were combined using a random effects model. Under the influence of other factors, the combined HR was 1.63 and 95%CI was 1.26-2.11. When the influence of other factors were excluded, the combined HR was 1.23 and 95%CI was 1.07-1.42. Conclusion High serum level of galectin-3 may be an independent risk factor for poor prognosis of CHF patients.
出处
《中华临床医师杂志（电子版）》
CAS
2013年第23期212-214,共3页
Chinese Journal of Clinicians(Electronic Edition)
基金
国家自然科学基金(81300070
81270303)
