摘要
目的研究左室射血分数(LVEF)、血管生成素2(Ang-2)与慢性心力衰竭(CHF)预后的相关性,以期为有效评估CHF患者预后提供有效指标。方法将2013年1月～2015年1月于河北省人民医院接受诊治的CHF患者129例为研究对象,对所有患者均进行为期3年的随访,根据随访结果将其分为生存组98例与死亡组31例。分别比较两组患者年龄、性别、体质指数(BMI)、糖尿病、高血压与心肌梗死等基本资料,收缩压、舒张压、LVEF、Ang-2及利钠肽(NP)等生化指标水平,并作多因素Logistic回归分析。结果与死亡组相比,生存组性别、年龄、BMI、糖尿病、高血压、心肌梗死差异无统计学意义(P均>0.05)。生存组收缩压、Ang-2、NP水平分别为(140.02±6.30)mmHg、(5.69±0.30)pg/ml、(2.70±0.28)pg/ml,低于死亡组的(145.05±6.11)mmHg、(5.92±0.17)pg/ml、(2.94±0.13)pg/ml,而LVEF为(47.54±3.97)%,高于死亡组的(43.29±3.27)%,差异均有统计学意义(P均<0.05)。经多因素Logistic回归分析,Ang-2是CHF死亡的独立危险因素,而LVEF是保护性因素(P均<0.05)。结论临床工作中可通过联合检测LVEF与Ang-2水平,对CHF患者的预后进行有效的评估。
Objective To study the correlation between left ventricular ejection fraction(LVEF)and angiopoietin 2(Ang-2)and the prognosis of chronic heart failure(CHF)with a view to providing effective indicators for the effective evaluation of the prognosis of patients with CHF.Methods 129 CHF patients treated in Hebei People's Hospital from January 2013 to January 2015 were selected as the research subjects.According to the follow-up results,they were divided into survival group(98 patients)and death group(31patients).The basic data of all patients,such as age,sex,body mass index(BMI),diabetes history,history of hypertension,and the history of myocardial infarction,systolic pressure,diastolic pressure,LVEF,Ang-2 and natriuretic peptide(NP)was compared.Results Compared with the death group,there was no significant difference in gender,age,BMI,history of diabetes,history of hypertension,and history of myocardial infarction in the survival group(all P>0.05).The systolic blood pressure,Ang-2,and NP levels in the survival group were(140.02±6.30)mmHg,(5.69±0.30)pg/ml,(2.70±0.28)pg/ml,which was lower than that of the death group(145.05±6.11)mmHg.(5.92±0.17)pg/ml,(2.94±0.13)pg/ml,and LVEF was(47.54±3.97)%,which was higher than death group(43.29±3.27)%,the difference was statistically significant(both P<0.05).After multivariate logistic regression analysis,Ang-2 was an independent risk factor for CHF death,while LVEF was a protective factor(both P<0.05).Conclusion Clinically,the prognosis of CHF patients can be effectively evaluated by jointly detecting LVEF and Ang-2 levels.
作者
王立立
耿彦平
杜荣品
Wang Lili;Geng Yanping;Du Rongping(Department of Cardiology,Hebei People's Hospital,Shijiazhuang 050051,China)
出处
《中国循证心血管医学杂志》
2018年第12期1500-1502,共3页
Chinese Journal of Evidence-Based Cardiovascular Medicine
基金
河北省医学科学研究重点课题计划(20180032)
关键词
慢性心力衰竭
左室射血分数
血管生成素2
预后评估
Chronic heart failure
Left ventricular ejection fraction
Angiogenin 2
Prognosis assessment
