摘要
目的：探讨合并真菌感染肺结核的临床表现及其耐药性。方法：回顾性分析2010年3月-2013年3月于我院治疗的133例肺结核并发真菌感染患者的临床资料。结果：133例并发真菌感染肺结核患者以合并下呼吸道细菌感染,低蛋白血症,糖尿病,广谱抗生素或糖皮质激素长时间使用患者为主。病原菌检测结果显示大部分为白色假丝酵母菌（72.18%）。两性霉素B、5-氟胞嘧啶和伊曲康唑是对真菌耐药率最低的常用抗真菌药物。经抗真菌治疗后,116例痰菌检测由阳性转变为阴性,11例没有变化,6例死亡,死亡率4.51%。结论：肺结核并发真菌感染患者有增加的趋势,对其病变特点及耐药情况,临床应予以重视。
Objective：To investigate the clinical features and drug resistance of pulmonary tuberculosis combined with fungal infection.Methods：133 cases with pulmonary tuberculosis combined with fungal infection were reviewed and analyzed.Results：Pulmonary tuberculosis combined with fungal infection mainly occurs in patients coupled with pulmonary bacteria infection,patients with hypoproteinemia,patients with diabetes,patients with Long-term use of broad-spectrum antibiotics or glucocorticoids.Pathogenic bacteria were mainly made of candida albicans,fungi had low drug resistance to amphotericin B,5-fluorocytosine and itraconazole.6 cases were dead,the mortality is 4.51%.Conclusion：Pulmonary tuberculosis combined with fungal infection have a growing trend in recent years,attention should be paid to the clinical features and drug resistance of it.
出处
《中国医药导刊》
2014年第2期317-318,共2页
Chinese Journal of Medicinal Guide
关键词
结核
真菌感染
肺
耐药性
Tuberculosis
Fungal infection
Lung
Drug resistance
