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维生素D在骨骼病变外的应用研究进展 被引量:5

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摘要 维生素D是一组脂溶性类固醇衍生物,是维持人体健康必不可少的营养素.人体内的维生素D主要来自阳光(紫外线B波段)照射皮肤后合成的维生素D3,其次来源于饮食如鱼类、蛋类和强化奶制品等的摄入,合成维生素D2或D3.维生素D3在肝内25羟化酶的作用下形成25-羟维生素D3[25 (OH) D3],然后在肾内1 α羟化酶的催化下成为活性更高的1,25-二羟基维生素D3 [1,25 (OH)2 D3].1,25(OH)2D3与体内靶细胞维生素D受体结合发挥生物效应.近年来,随着对维生素D作用研究的深入,发现维生素D缺乏除导致骨骼病变外,不仅影响钙磷代谢,还具有越来越多的生物学效应,如调节激素分泌、影响免疫功能、调节细胞增生与分化,从而与多种疾病的发生发展密切相关.
出处 《中国医药》 2014年第4期606-608,共3页 China Medicine
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参考文献17

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共引文献49

同被引文献37

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